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Tbio
HRK
Activator of apoptosis harakiri

Protein Summary
Description
Promotes apoptosis. This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257572
  • ENSP00000257572
  • ENSG00000135116

Symbol
  • BID3
  • DP5
  • HARAKIRI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.84
cell type or tissue
0.79
transcription factor binding site profile
0.64
transcription factor
0.62
tissue
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.77   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.77   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hippocampal volume
4
2
0
59.1
97.3
brain volume measurement
1
2
0
52
81.7
brain measurement
1
1
0
47.6
42.3
hippocampal CA1 volume
1
1
0
24.1
21.4
granule cell layer dentate gyrus volume
1
1
0
11
20.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hippocampal volume
0
59.1
97.3
brain volume measurement
0
52
81.7
brain measurement
0
47.6
42.3
hippocampal CA1 volume
0
24.1
21.4
granule cell layer dentate gyrus volume
0
11
20.3
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
harakiri, BCL2 interacting protein
VGNC:13144
742172
Mouse
MGI:1201608
12123
Dog
harakiri, BCL2 interacting protein
VGNC:41789
612984
Cow
harakiri, BCL2 interacting protein
VGNC:29957
787139
Opossum
harakiri, BCL2 interacting protein
100013560
Species
Name
OMA
EggNOG
Inparanoid
Chimp
harakiri, BCL2 interacting protein
Mouse
Dog
harakiri, BCL2 interacting protein
Cow
harakiri, BCL2 interacting protein
Opossum
harakiri, BCL2 interacting protein
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00198-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (39)
1 – 10 of 39
BCL2L2
Tchem
Novelty: 0.00430896
Score: 0.932
Data Source: STRINGDB
MCL1
Tchem
Novelty: 0.00046181
Score: 0.905
Data Source: STRINGDB
BCL2L1
Tchem
Novelty: 0.00018414
Score: 0.901
Data Source: STRINGDB
BCL2A1
Tchem
Novelty: 0.00088899
Score: 0.886
Data Source: STRINGDB
BMF
Tbio
Novelty: 0.01021679
Score: 0.836
Data Source: STRINGDB
BCL2L11
Tbio
Novelty: 0.00055914
Score: 0.809
Data Source: STRINGDB
PMAIP1
Tbio
Novelty: 0.00198406
Score: 0.801
Data Source: STRINGDB
BIK
Tbio
Novelty: 0.0046334
Score: 0.798
Data Source: STRINGDB
TFDP3
Tbio
Family: TF
Novelty: 0.00223003
Score: 0.797
Data Source: STRINGDB
BCL2
Tclin
Novelty: 0.00608635
Score: 0.727
Data Source: STRINGDB
Publication Statistics
PubMed Score  316.77

PubMed score by year
PubTator Score  84.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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