Tbio AP4M1 AP-4 complex subunit mu-1

Protein Summary

Description

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10436028, PubMed:11139587, PubMed:10066790, PubMed:11802162, PubMed:20230749). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (PubMed:11139587, PubMed:20230749). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (By similarity). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (PubMed:10436028, PubMed:11139587, PubMed:26544806, PubMed:20230749). The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity). This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00189
• D6W5U1
• Q8WV65
• Q9UHK9

Gene Name

• AP4M1

Ensembl ID

• ENST00000359593
• ENSP00000352603
• ENSG00000221838
• ENST00000421755
• ENSP00000412185

Symbol

• MUARP2
• MU-4
• CPSQ3
• SPG50
• MU-ARP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
transcription factor binding site profile	0.82
cellular component	0.68
histone modification site profile	0.63
transcription factor	0.63

Protein Classes

PANTHER Classes

Protein / Receptor / Ap-4 Complex Subunit Mu-1

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Ap-4 Complex Subunit Mu-1

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Ap-4 Complex Subunit Mu-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1236.44   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 171   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1236.44   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0