Tchem MASP2 Mannan-binding lectin serine protease 2

Protein Summary

Description

Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• O00187
• A8K458
• A8MWJ2
• O75754
• Q5TEQ5
• Q5TER0
• Q96QG4
• Q9BZH0
• Q9H498
• Q9H499
• Q9UBP3
• Q9UC48
• Q9ULC7
• Q9UMV3
• Q9Y270

Gene Name

• MASP2

Ensembl ID

• ENST00000400897
• ENSP00000383690
• ENSG00000009724
• ENST00000400898
• ENSP00000383691

Symbol

• sMAP
• MAP19
• MASP-2
• MASP1P1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
virus perturbation	0.79
biological term	0.71
co-expressed gene	0.69
disease	0.67

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Mannan-binding Lectin Serine Protease 2

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Mannan-binding Lectin Serine Protease 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.11   (req: < 5)

Gene RIFs: 102   (req: <= 3)

Antibodies: 308   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.11   (req: >= 5)

Gene RIFs: 102   (req: > 3)

Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0