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Tbio
MASP2
Mannan-binding lectin serine protease 2

Protein Summary
Description
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
0.79
biological term
0.71
co-expressed gene
0.69
disease
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.29   (req: < 5)
Gene RIFs: 81   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.29   (req: >= 5)
Gene RIFs: 81   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
77
eosinophil percentage of leukocytes
1
1
1
14.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
77
eosinophil percentage of leukocytes
1
14.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannan binding lectin serine peptidase 2
VGNC:8389
736039
Macaque
mannan binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902]
Mouse
MGI:1330832
17175
Rat
RGD:620214
64459
Dog
mannan binding lectin serine peptidase 2
VGNC:43031
487447
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannan binding lectin serine peptidase 2
Macaque
mannan binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902]
Mouse
Rat
Dog
mannan binding lectin serine peptidase 2
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00187-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Reactome
Immune System
Reactome
Initial triggering of complement
Name
Explore in Pharos
Explore in Source
Complement cascade
Creation of C4 and C2 activators
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Immune System
Initial triggering of complement
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (47)
1 – 10 of 47
MBL2
Tbio
Novelty: 0.00124156
Score: 0.99
Data Source: Reactome,STRINGDB
C4B
Tbio
Novelty: 0.00068357
Score: 0.986
Data Source: Reactome,STRINGDB
C4A
Tbio
Novelty: 0.00062793
Score: 0.986
Data Source: Reactome,STRINGDB
SERPING1
Tbio
Family: Enzyme
Novelty: 0.00068448
Score: 0.953
Data Source: STRINGDB
FCN2
Tbio
Novelty: 0.00519137
Score: 0.951
Data Source: Reactome,STRINGDB
MASP1
Tbio
Family: Enzyme
Novelty: 0.0029019
Score: 0.935
Data Source: Reactome,STRINGDB
FCN3
Tbio
Novelty: 0.00771958
Score: 0.908
Data Source: Reactome,STRINGDB
C2
Tbio
Novelty: 0.00974862
Score: 0.842
Data Source: Reactome,STRINGDB
FCN1
Tbio
Novelty: 0.01037775
Score: 0.818
Data Source: Reactome,STRINGDB
C8B
Tbio
Novelty: 0.00873524
Score: 0.77
Data Source: STRINGDB
Publication Statistics
PubMed Score  235.29

PubMed score by year
PubTator Score  186.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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