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Tbio
STXBP3
Syntaxin-binding protein 3

Protein Summary
Description
Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370008
  • ENSP00000359025
  • ENSG00000116266

Symbol
  • PSP
  • MUNC18C
  • UNC-18C
  • MUNC18-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
biological process
0.77
transcription factor binding site profile
0.74
virus perturbation
0.72
histone modification site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.11   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.11   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
STX4
Tbio
Novelty:  0.00831588
p_int:  0.999997247
p_ni:  0.000002753
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TMEM97
Tchem
Novelty:  0.00597439
p_int:  0.99665991
p_ni:  0.00334009
Score:  0.534
Data Source:  BioPlex,STRINGDB
SLC35F2
Tbio
Family:  Transporter
Novelty:  0.08323418
p_int:  0.992561957
p_ni:  0.007438043
Data Source:  BioPlex
AAGAB
Tbio
Novelty:  0.0479209
p_int:  0.987583678
p_ni:  0.012416322
Score:  0.359
Data Source:  BioPlex,STRINGDB
PLPPR1
Tdark
Family:  Enzyme
Novelty:  0.38109551
p_int:  0.985326131
p_ni:  0.014673869
Score:  0.792
Data Source:  BioPlex,STRINGDB
ASPH
Tbio
Family:  Enzyme
Novelty:  0.00291455
p_int:  0.965632838
p_ni:  0.034367162
Data Source:  BioPlex
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.956042233
p_ni:  0.043957767
Data Source:  BioPlex
GPR141
Tdark
Family:  GPCR
Novelty:  0.30711523
p_int:  0.912930646
p_ni:  0.087069354
Score:  0.666
Data Source:  BioPlex,STRINGDB
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.912326622
p_ni:  0.087673378
Data Source:  BioPlex
ICMT
Tchem
Family:  Enzyme
Novelty:  0.00706181
p_int:  0.882079822
p_ni:  0.117920178
Score:  0.205
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Disinhibition of SNARE formation (R-HSA-114516)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disinhibition of SNARE formation
Reactome
Hemostasis
Reactome
Membrane Trafficking
Reactome
Platelet activation, signaling and aggregation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Disinhibition of SNARE formation
Hemostasis
Membrane Trafficking
Platelet activation, signaling and aggregation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
2
2
75
low density lipoprotein cholesterol measurement
1
2
2
63
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
75
low density lipoprotein cholesterol measurement
2
63
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 3
VGNC:1652
737947
Macaque
syntaxin binding protein 3
699144
Mouse
MGI:107362
20912
Rat
RGD:619968
114095
Dog
syntaxin binding protein 3
VGNC:46961
490128
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin binding protein 3
Macaque
syntaxin binding protein 3
Mouse
Rat
Dog
syntaxin binding protein 3
Publication Statistics
PubMed Score 31.11
PubMed score by year
PubTator Score 23.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title