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Tbio
KCNK1
Potassium channel subfamily K member 1

Protein Summary
Description
Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366621
  • ENSP00000355580
  • ENSG00000135750

Symbol
  • HOHO1
  • KCNO1
  • TWIK1
  • DPK
  • HOHO
  • K2P1
  • KCNO1
  • TWIK1
  • K2p1.1
  • TWIK-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
gene perturbation
0.96
molecular function
0.9
transcription factor perturbation
0.84
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.8   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.8   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 4 - resting membrane potential
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 4 - resting membrane potential
Potassium Channels
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (68)
1 – 10 of 68
SENP1
Tchem
Family: Enzyme
Novelty: 0.00831213
Score: 0.755
Data Source: STRINGDB
NUDT6
Tbio
Novelty: 0.03648851
Score: 0.753
Data Source: STRINGDB
SLC35F3
Tbio
Family: Transporter
Novelty: 0.3221418
Score: 0.744
Data Source: STRINGDB
PSD
Tbio
Novelty: 0.01135204
Score: 0.691
Data Source: STRINGDB
KCNJ3
Tchem
Family: IC
Novelty: 0.00373765
Score: 0.689
Data Source: STRINGDB
KCNIP3
Tbio
Family: IC
Novelty: 0.01371555
Score: 0.664
Data Source: STRINGDB
PHF10
Tbio
Family: Epigenetic
Novelty: 0.05941323
Score: 0.646
Data Source: STRINGDB
UBE2I
Tbio
Novelty: 0.00267883
Score: 0.638
Data Source: STRINGDB
KCNH2
Tclin
Family: IC
Novelty: 0.00041611
Score: 0.625
Data Source: STRINGDB
SUMO1
Tbio
Novelty: 0.00137629
Score: 0.613
Data Source: STRINGDB
Publication Statistics
PubMed Score  88.80

PubMed score by year
PubTator Score  45.64

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer