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Tbio
AIP
AH receptor-interacting protein

Protein Classes
Protein Summary
Description
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Cellular negative regulator of the hepatitis B virus (HBV) X protein. The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279146
  • ENSP00000279146
  • ENSG00000110711

Symbol
  • XAP2
  • ARA9
  • XAP2
  • PITA1
  • XAP-2
  • FKBP16
  • FKBP37
  • SMTPHN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor binding site profile
0.83
cell type or tissue
0.75
tissue sample
0.72
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.11   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.11   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Aryl hydrocarbon receptor signalling (R-HSA-8937144)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aryl hydrocarbon receptor signalling
Reactome
Biological oxidations
Reactome
Cytokine Signaling in Immune system
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Aryl hydrocarbon receptor signalling
Biological oxidations
Cytokine Signaling in Immune system
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Immune System
Protein-Protein Interactions (58)
1 – 10 of 58
SYCN
Tbio
Novelty: 0.0354405
p_int: 0.992185636
p_ni: 0.007814364
Data Source: BioPlex
TDGF1
Tbio
Novelty: 0.00527099
p_int: 0.966939174
p_ni: 0.033060826
Score: 0.198
Data Source: BioPlex,STRINGDB
PRAMEF17
Tdark
Novelty: 3.36925974
p_int: 0.964608734
p_ni: 0.035391266
Score: 0.816
Data Source: BioPlex,STRINGDB
CDK9
Tchem
Family: Kinase
Novelty: 0.00210218
p_int: 0.96410285
p_ni: 0.03589715
Score: 0.582
Data Source: BioPlex,STRINGDB
AGO1
Tbio
Novelty: 0.00157424
p_int: 0.955519482
p_ni: 0.044480518
Data Source: BioPlex
PRAMEF10
Tdark
Novelty: 2.84278565
p_int: 0.940340853
p_ni: 0.059659146
Score: 0.837
Data Source: BioPlex,STRINGDB
KHDC1
Tbio
Novelty: 0.13778027
p_int: 0.909424784
p_ni: 0.090575216
Data Source: BioPlex
RLN2
Tbio
Novelty: 0.00743118
p_int: 0.898341317
p_ni: 0.101658683
Data Source: BioPlex
CCDC120
Tbio
Novelty: 0.48574876
p_int: 0.849377209
p_ni: 0.150622791
Data Source: BioPlex
NEU4
Tchem
Family: Enzyme
Novelty: 0.02621605
p_int: 0.817808211
p_ni: 0.182191789
Score: 0.188
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  103.11

PubMed score by year
PubTator Score  132.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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