Protein Classes
Protein Summary
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phosphol ...more
- ENST00000351325
- ENSP00000343314
- ENSG00000266964
- ENST00000455515
- ENSP00000393611
- ENST00000588081
- ENSP00000467727
- ENST00000588607
- ENSP00000468535
- ENST00000588715
- ENSP00000465289
- ENST00000589209
- ENSP00000466398
- ENST00000612146
- ENSP00000481244
- PLM
- PLM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.95 | ||
gene perturbation | 0.86 | ||
molecular function | 0.73 | ||
PubMedID | 0.69 | ||
tissue | 0.67 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 578.76 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 266 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 578.76 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 266 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (7)
Reactome (6)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cardiac conduction | ||||
Reactome | Ion channel transport | ||||
Reactome | Ion homeostasis | ||||
Reactome | Ion transport by P-type ATPases | ||||
Reactome | Muscle contraction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cardiac conduction | ||||
Ion channel transport | ||||
Ion homeostasis | ||||
Ion transport by P-type ATPases | ||||
Muscle contraction | ||||
Gene Ontology Terms (20)
Functions (3)
Components (8)
Processes (9)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (61)
1 – 10 of 61
NDRG1
Novelty: 0.00461958
p_int: 0.9999995
p_ni: 5e-7
Score: 0.221
Data Source: BioPlex,STRINGDB
NDRG3
Novelty: 0.08172796
p_int: 0.999998347
p_ni: 4.4e-7
p_wrong: 0.000001214
Score: 0.355
Data Source: BioPlex,STRINGDB
NDRG4
Novelty: 0.03294902
p_int: 0.999988531
p_ni: 0.000005689
p_wrong: 0.00000578
Score: 0.266
Data Source: BioPlex,STRINGDB
THNSL1
Family: Enzyme
p_int: 0.999979452
p_ni: 0.000020548
Score: 0.175
Data Source: BioPlex,STRINGDB
GCHFR
Family: Enzyme
Novelty: 0.01858928
p_int: 0.999206635
p_ni: 0.000793365
Score: 0.157
Data Source: BioPlex,STRINGDB
ATP6V1D
Family: Enzyme
Novelty: 0.03173315
p_int: 0.997324893
p_ni: 0.002675105
p_wrong: 2e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
GOPC
Novelty: 0.0164207
p_int: 0.990671961
p_ni: 0.009328039
Data Source: BioPlex
FAM204A
p_int: 0.870622443
p_ni: 0.108573801
p_wrong: 0.020803755
Score: 0.345
Data Source: BioPlex,STRINGDB
PRTFDC1
Family: Enzyme
Novelty: 0.15441176
p_int: 0.83082914
p_ni: 0.02937574
p_wrong: 0.13979512
Score: 0.157
Data Source: BioPlex,STRINGDB
POLE4
Family: Enzyme
Novelty: 0.30757964
p_int: 0.828618347
p_ni: 0.17130928
p_wrong: 0.000072372
Score: 0.232
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 578.76
PubMed score by year
PubTator Score 216.76
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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