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Tbio
FXYD1
Phospholemman

Protein Summary
Description
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phosphol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351325
  • ENSP00000343314
  • ENSG00000266964
  • ENST00000455515
  • ENSP00000393611
  • ENST00000588081
  • ENSP00000467727
  • ENST00000588607
  • ENSP00000468535
  • ENST00000588715
  • ENSP00000465289
  • ENST00000589209
  • ENSP00000466398
  • ENST00000612146
  • ENSP00000481244

Symbol
  • PLM
  • PLM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
gene perturbation
0.86
molecular function
0.73
PubMedID
0.69
tissue
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.76   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.76   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Muscle contraction
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (61)
1 – 10 of 61
NDRG1
Tbio
Novelty: 0.00461958
p_int: 0.9999995
p_ni: 5e-7
Score: 0.221
Data Source: BioPlex,STRINGDB
NDRG3
Tbio
Novelty: 0.08172796
p_int: 0.999998347
p_ni: 4.4e-7
p_wrong: 0.000001214
Score: 0.355
Data Source: BioPlex,STRINGDB
NDRG4
Tbio
Novelty: 0.03294902
p_int: 0.999988531
p_ni: 0.000005689
p_wrong: 0.00000578
Score: 0.266
Data Source: BioPlex,STRINGDB
THNSL1
Tdark
Family: Enzyme
p_int: 0.999979452
p_ni: 0.000020548
Score: 0.175
Data Source: BioPlex,STRINGDB
GCHFR
Tbio
Family: Enzyme
Novelty: 0.01858928
p_int: 0.999206635
p_ni: 0.000793365
Score: 0.157
Data Source: BioPlex,STRINGDB
ATP6V1D
Tbio
Family: Enzyme
Novelty: 0.03173315
p_int: 0.997324893
p_ni: 0.002675105
p_wrong: 2e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
GOPC
Tbio
Novelty: 0.0164207
p_int: 0.990671961
p_ni: 0.009328039
Data Source: BioPlex
FAM204A
Tdark
p_int: 0.870622443
p_ni: 0.108573801
p_wrong: 0.020803755
Score: 0.345
Data Source: BioPlex,STRINGDB
PRTFDC1
Tbio
Family: Enzyme
Novelty: 0.15441176
p_int: 0.83082914
p_ni: 0.02937574
p_wrong: 0.13979512
Score: 0.157
Data Source: BioPlex,STRINGDB
POLE4
Tdark
Family: Enzyme
Novelty: 0.30757964
p_int: 0.828618347
p_ni: 0.17130928
p_wrong: 0.000072372
Score: 0.232
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  578.76

PubMed score by year
PubTator Score  216.76

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer