Tbio FXYD1 Phospholemman

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Phospholemman

Protein / Enzyme Modulator / Phospholemman

Protein Summary

Description

Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00168
• A8K196

Gene Name

• FXYD1

Ensembl ID

• ENST00000351325
• ENSP00000343314
• ENSG00000266964
• ENST00000455515
• ENSP00000393611
• ENST00000588081
• ENSP00000467727
• ENST00000588607
• ENSP00000468535
• ENST00000588715
• ENSP00000465289
• ENST00000589209
• ENSP00000466398
• ENST00000612146
• ENSP00000481244

Symbol

• PLM
• PLM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
gene perturbation	0.86
molecular function	0.73
PubMedID	0.69
tissue	0.67

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.76   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 266   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.76   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (7)

Reactome (6)

KEGG (1)

Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cardiac conduction	137 targets	R-HSA-5576891
Reactome	Ion channel transport	179 targets	R-HSA-983712
Reactome	Ion homeostasis	52 targets	R-HSA-5578775
Reactome	Ion transport by P-type ATPases	55 targets	R-HSA-936837
Reactome	Muscle contraction	202 targets	R-HSA-397014

Name	Explore in Pharos	Explore in Source
Cardiac conduction	137 targets	R-HSA-5576891
Ion channel transport	179 targets	R-HSA-983712
Ion homeostasis	52 targets	R-HSA-5578775
Ion transport by P-type ATPases	55 targets	R-HSA-936837
Muscle contraction	202 targets	R-HSA-397014

Gene Ontology Terms (20)

Functions (3)

Components (8)

Processes (9)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
ion channel binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
sodium channel regulator activity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
chloride channel activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (61)

Explore Interacting Targets

1 – 10 of 61

• See Interactions on String-DB

NDRG1

Tbio

Novelty: 0.00461958

p_int: 0.9999995

p_ni: 5e-7

Score: 0.221

Data Source: BioPlex,STRINGDB

NDRG3

Tbio

Novelty: 0.08172796

p_int: 0.999998347

p_ni: 4.4e-7

p_wrong: 0.000001214

Score: 0.355

Data Source: BioPlex,STRINGDB

NDRG4

Tbio

Novelty: 0.03294902

p_int: 0.999988531

p_ni: 0.000005689

p_wrong: 0.00000578

Score: 0.266

Data Source: BioPlex,STRINGDB

THNSL1

Tdark

Family: Enzyme

p_int: 0.999979452

p_ni: 0.000020548

Score: 0.175

Data Source: BioPlex,STRINGDB

GCHFR

Tbio

Family: Enzyme

Novelty: 0.01858928

p_int: 0.999206635

p_ni: 0.000793365

Score: 0.157

Data Source: BioPlex,STRINGDB

ATP6V1D

Tbio

Family: Enzyme

Novelty: 0.03173315

p_int: 0.997324893

p_ni: 0.002675105

p_wrong: 2e-9

Score: 0.173

Data Source: BioPlex,STRINGDB

GOPC

Tbio

Novelty: 0.0164207

p_int: 0.990671961

p_ni: 0.009328039

Data Source: BioPlex

FAM204A

Tdark

p_int: 0.870622443

p_ni: 0.108573801

p_wrong: 0.020803755

Score: 0.345

Data Source: BioPlex,STRINGDB

PRTFDC1

Tbio

Family: Enzyme

Novelty: 0.15441176

p_int: 0.83082914

p_ni: 0.02937574

p_wrong: 0.13979512

Score: 0.157

Data Source: BioPlex,STRINGDB

POLE4

Tdark

Family: Enzyme

Novelty: 0.30757964

p_int: 0.828618347

p_ni: 0.17130928

p_wrong: 0.000072372

Score: 0.232

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  578.76

PubMed score by year

Reset Zoom

PubTator Score  216.76

PubTator score by year

Reset Zoom

Patents

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Cell membrane
Complete proteome
Glutathionylation
Ion transport
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Potassium

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
muscle phenotype