Tbio EYA2 Eyes absent homolog 2

Protein Summary

Description

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905). This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined. [provided by RefSeq, Jul 2009]

Uniprot Accession IDs

• O00167
• Q5JSW8
• Q86U84
• Q96CV6
• Q96H97
• Q99503
• Q99812
• Q9BWF6
• Q9H4S3
• Q9H4S9
• Q9NPZ4
• Q9UIX7

Gene Name

• EYA2

Ensembl ID

• ENST00000327619
• ENSP00000333640
• ENSG00000064655
• ENST00000357410
• ENSP00000349986
• ENST00000497062
• ENSP00000417105

Symbol

• EAB1
• EAB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
PubMedID	0.85
virus perturbation	0.83
biological process	0.75
gene perturbation	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.12   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 246   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.12   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0