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Tbio
EYA2
Eyes absent homolog 2

Protein Summary
Description
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905). This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can ac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327619
  • ENSP00000333640
  • ENSG00000064655
  • ENST00000357410
  • ENSP00000349986
  • ENST00000497062
  • ENSP00000417105

Symbol
  • EAB1
  • EAB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
PubMedID
0.85
virus perturbation
0.83
biological process
0.75
gene perturbation
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.65   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.65   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
SIX2
Tbio
Family:  TF
Novelty:  0.01046481
p_int:  0.999310733
p_ni:  1.5e-8
p_wrong:  0.000689252
Score:  0.842
Data Source:  BioPlex,STRINGDB
CCDC85C
Tbio
Novelty:  0.30053883
p_int:  0.848379868
p_ni:  0.145106868
p_wrong:  0.006513264
Score:  0.29
Data Source:  BioPlex,STRINGDB
SIX1
Tbio
Family:  TF
Novelty:  0.00415613
Score:  0.963
Data Source:  STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
Score:  0.922
Data Source:  STRINGDB
NBN
Tbio
Novelty:  0.00759456
Score:  0.911
Data Source:  STRINGDB
MDC1
Tbio
Novelty:  0.00533097
Score:  0.909
Data Source:  STRINGDB
EYA3
Tbio
Novelty:  0.05588286
Score:  0.907
Data Source:  STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.906
Data Source:  Reactome,STRINGDB
EYA4
Tbio
Novelty:  0.01905381
Score:  0.903
Data Source:  STRINGDB
EYA1
Tbio
Novelty:  0.00585286
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
DNA Double Strand Break Response (R-HSA-5693606)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Name
Explore in Pharos
Explore in Source
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
10
23
33
98.8
waist-hip ratio
5
20
26
97
heel bone mineral density
3
5
7
97
hip circumference
2
17
18
93.2
BMI-adjusted hip circumference
2
13
15
91.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
33
98.8
waist-hip ratio
26
97
heel bone mineral density
7
97
hip circumference
18
93.2
BMI-adjusted hip circumference
15
91.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EYA transcriptional coactivator and phosphatase 2
VGNC:9856
458305
Macaque
EYA transcriptional coactivator and phosphatase 2
716182
Mouse
MGI:109341
14049
Rat
RGD:620096
156826
Dog
EYA transcriptional coactivator and phosphatase 2
VGNC:40537
609926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EYA transcriptional coactivator and phosphatase 2
Macaque
EYA transcriptional coactivator and phosphatase 2
Mouse
Rat
Dog
EYA transcriptional coactivator and phosphatase 2
Publication Statistics
PubMed Score 60.65
PubMed score by year
PubTator Score 25.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title