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Tbio
SNAP23
Synaptosomal-associated protein 23

Protein Summary
Description
Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249647
  • ENSP00000249647
  • ENSG00000092531
  • ENST00000349777
  • ENSP00000207062
  • ENST00000397138
  • ENSP00000380327

Symbol
  • SNAP-23
  • SNAP23A
  • SNAP23B
  • HsT17016
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
transcription factor perturbation
0.91
cellular component
0.84
tissue
0.69
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.17   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.17   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (108)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
ER-Phagosome pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
ER-Phagosome pathway
Immune System
Gene Ontology Terms (28)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (340)
1 – 10 of 340
SCGN
Tbio
Novelty: 0.01547867
p_int: 0.995331781
p_ni: 0.004668219
Score: 0.441
Data Source: BioPlex,STRINGDB
STX7
Tbio
Novelty: 0.052457
p_int: 0.980198823
p_ni: 0.019801177
Score: 0.966
Data Source: BioPlex,STRINGDB
STX12
Tbio
Novelty: 0.07003045
p_int: 0.960101264
p_ni: 0.039898736
Score: 0.987
Data Source: BioPlex,STRINGDB
STX19
Tdark
Novelty: 3.68421053
p_int: 0.945474098
p_ni: 0.054525902
Score: 0.843
Data Source: BioPlex,STRINGDB
STX11
Tbio
Novelty: 0.02724724
p_int: 0.918872409
p_ni: 0.081127591
Score: 0.968
Data Source: BioPlex,STRINGDB
STXBP6
Tbio
Novelty: 0.18615646
p_int: 0.910649774
p_ni: 0.089350226
Score: 0.827
Data Source: BioPlex,STRINGDB
CHMP2A
Tbio
Novelty: 0.00337804
p_int: 0.864122703
p_ni: 0.135877207
p_wrong: 9e-8
Score: 0.226
Data Source: BioPlex,STRINGDB
VAMP4
Tbio
Novelty: 0.04197927
p_int: 0.774826035
p_ni: 0.225173965
Score: 0.981
Data Source: BioPlex,STRINGDB
GJB7
Tdark
Novelty: 0.28301887
p_int: 0.767724178
p_ni: 0.232275822
Data Source: BioPlex
STX1A
Tbio
Novelty: 0.00128938
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  140.17

PubMed score by year
PubTator Score  105.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer