Tbio SNAP23 Synaptosomal-associated protein 23

Protein Summary

Description

Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00161
• O00162
• Q13602
• Q6IAE3
• SNAP-23

Gene Name

• SNAP23

Ensembl ID

• ENST00000249647
• ENSP00000249647
• ENSG00000092531
• ENST00000349777
• ENSP00000207062
• ENST00000397138
• ENSP00000380327

Symbol

• SNAP-23
• SNAP23A
• SNAP23B
• HsT17016

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.97
transcription factor perturbation	0.91
cellular component	0.84
tissue	0.69
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Synaptosomal-associated Protein 23

DTO Classes

Protein / Transporter / Snare Protein / Synaptosomal-associated Protein 23

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.28   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 389   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.28   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0