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Tbio
SNAP23
Synaptosomal-associated protein 23

Protein Summary
Description
Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion. Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249647
  • ENSP00000249647
  • ENSG00000092531
  • ENST00000349777
  • ENSP00000207062
  • ENST00000397138
  • ENSP00000380327

Symbol
  • SNAP-23
  • SNAP23A
  • SNAP23B
  • HsT17016
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
transcription factor perturbation
0.91
cellular component
0.84
tissue
0.69
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.01   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.01   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
6
3
6
7
92.9
IGF-1 measurement
1
1
1
78.4
serum albumin measurement
1
1
1
76.7
red blood cell density measurement
1
1
1
67.9
high density lipoprotein cholesterol measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
6
7
92.9
IGF-1 measurement
1
78.4
serum albumin measurement
1
76.7
red blood cell density measurement
1
67.9
high density lipoprotein cholesterol measurement
1
57.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptosome associated protein 23
VGNC:3528
453365
Macaque
synaptosome associated protein 23
708225
Mouse
MGI:109356
20619
Dog
synaptosome associated protein 23
VGNC:46587
478268
Horse
synaptosome associated protein 23
VGNC:23373
100056719
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptosome associated protein 23
Macaque
synaptosome associated protein 23
Mouse
Dog
synaptosome associated protein 23
Horse
synaptosome associated protein 23
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00161-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (108)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
ER-Phagosome pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
ER-Phagosome pathway
Immune System
Gene Ontology Terms (28)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (340)
1 – 10 of 340
SCGN
Tbio
Novelty:  0.01434518
p_int:  0.995331781
p_ni:  0.004668219
Score:  0.441
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.980198823
p_ni:  0.019801177
Score:  0.966
Data Source:  BioPlex,STRINGDB
STX12
Tbio
Novelty:  0.03836262
p_int:  0.960101264
p_ni:  0.039898736
Score:  0.987
Data Source:  BioPlex,STRINGDB
STX19
Tdark
Novelty:  0.99387951
p_int:  0.945474098
p_ni:  0.054525902
Score:  0.843
Data Source:  BioPlex,STRINGDB
STX11
Tbio
Novelty:  0.01670743
p_int:  0.918872409
p_ni:  0.081127591
Score:  0.968
Data Source:  BioPlex,STRINGDB
STXBP6
Tbio
Novelty:  0.13195671
p_int:  0.910649774
p_ni:  0.089350226
Score:  0.827
Data Source:  BioPlex,STRINGDB
CHMP2A
Tbio
Novelty:  0.00169253
p_int:  0.864122703
p_ni:  0.135877207
p_wrong:  9e-8
Score:  0.226
Data Source:  BioPlex,STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.774826035
p_ni:  0.225173965
Score:  0.981
Data Source:  BioPlex,STRINGDB
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.767724178
p_ni:  0.232275822
Data Source:  BioPlex
STX1A
Tbio
Novelty:  0.00087207
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  164.01

PubMed score by year
PubTator Score  105.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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