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Tbio
MYO1C
Unconventional myosin-Ic

Protein Summary
Description
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity). This ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359786
  • ENSP00000352834
  • ENSG00000197879
  • ENST00000361007
  • ENSP00000354283
  • ENST00000438665
  • ENSP00000412197
  • ENST00000570984
  • ENSP00000459271
  • ENST00000575158
  • ENSP00000459174
  • ENST00000646049
  • ENSP00000493973
  • ENST00000648446
  • ENSP00000496799
  • ENST00000648651
  • ENSP00000496954

Symbol
  • NMI
  • MMIb
  • myr2
  • MMI-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.99
transcription factor perturbation
0.97
transcription factor
0.91
biological process
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.38   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.38   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
81.8
neutrophil count
2
1
2
77.3
myeloid white cell count
1
1
1
69.3
appendicular lean mass
2
1
2
56.8
leukocyte count
1
1
1
24.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
81.8
neutrophil count
2
77.3
myeloid white cell count
1
69.3
appendicular lean mass
2
56.8
leukocyte count
1
24.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin IC
VGNC:12494
750403
Macaque
myosin IC
721217
Mouse
MGI:106612
17913
Rat
RGD:620443
65261
Dog
myosin IC
VGNC:43562
100855443
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin IC
Macaque
myosin IC
Mouse
Rat
Dog
myosin IC
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00159-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (156)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Gene expression (Transcription)
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Epigenetic regulation of gene expression
Fcgamma receptor (FCGR) dependent phagocytosis
Gene expression (Transcription)
Immune System
Gene Ontology Terms (42)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (143)
1 – 10 of 143
UNC45A
Tbio
Novelty: 0.07503761
p_int: 0.884279549
p_ni: 0.115720451
Score: 0.707
Data Source: BioPlex,STRINGDB
RALA
Tbio
Family: Enzyme
Novelty: 0.00257914
Score: 0.976
Data Source: Reactome,STRINGDB
SLC2A4
Tbio
Family: Transporter
Novelty: 0.00033701
Score: 0.971
Data Source: STRINGDB
EXOC7
Tbio
Novelty: 0.00852508
Score: 0.944
Data Source: STRINGDB
MYO5A
Tbio
Novelty: 0.00373224
Score: 0.943
Data Source: STRINGDB
RAB10
Tbio
Family: Enzyme
Novelty: 0.00870713
Score: 0.941
Data Source: STRINGDB
EXOC2
Tbio
Novelty: 0.01434464
Score: 0.94
Data Source: STRINGDB
ACTR2
Tbio
Novelty: 0.00731489
Score: 0.939
Data Source: STRINGDB
EXOC4
Tbio
Novelty: 0.01636648
Score: 0.939
Data Source: STRINGDB
ARPC1B
Tbio
Novelty: 0.03873325
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score  107.38

PubMed score by year
PubTator Score  68.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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