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Tdark
GPR25
Probable G-protein coupled receptor 25

Protein Summary
Description
Orphan receptor. This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. This gene has been linked to arterial stiffness. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304244
  • ENSP00000301917
  • ENSG00000170128
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.6
gene perturbation
0.47
cell line
0.46
tissue sample
0.46
protein complex
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.76   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.76   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (140)
GPR27
Tbio
Family:  GPCR
Novelty:  0.164488
Score:  0.951
Data Source:  STRINGDB
GPR150
Tdark
Family:  GPCR
Novelty:  0.91287003
Score:  0.949
Data Source:  STRINGDB
GPR176
Tdark
Family:  GPCR
Novelty:  0.28180289
Score:  0.945
Data Source:  STRINGDB
GPR39
Tchem
Family:  GPCR
Novelty:  0.01244607
Score:  0.936
Data Source:  STRINGDB
GNG4
Tbio
Novelty:  0.14371438
Score:  0.934
Data Source:  STRINGDB
GPHA2
Tbio
Novelty:  0.01057969
Score:  0.933
Data Source:  STRINGDB
GPR15
Tbio
Family:  GPCR
Novelty:  0.00673057
Score:  0.921
Data Source:  STRINGDB
GPR84
Tchem
Family:  GPCR
Novelty:  0.02360587
Score:  0.921
Data Source:  STRINGDB
GPR20
Tdark
Family:  GPCR
Novelty:  0.34435286
Score:  0.919
Data Source:  STRINGDB
GPR32
Tchem
Family:  GPCR
Novelty:  0.0551913
Score:  0.916
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.2
90.3
3
3
0
1.1
88.9
2
2
0
1.2
83.4
1
1
0
1.2
80.6
1
1
0
1.2
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
90.3
0
1.1
88.9
0
1.2
83.4
0
1.2
80.6
0
1.2
65.5
Find similar targets by:
IDG Resources
Genetic Construct
GPR25-Tango
image for GPR25-Tango
Details:
  • Vector:  addgene66347
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR25-Tango
Order Genetic Construct from:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 25
VGNC:8043
469633
Macaque
G protein-coupled receptor 25
709001
Mouse
MGI:2686146
383563
Rat
RGD:1311611
363993
Dog
G protein-coupled receptor 25
VGNC:41427
608291
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 25
Macaque
G protein-coupled receptor 25
Mouse
Rat
Dog
G protein-coupled receptor 25
Publication Statistics
PubMed Score 2.76
PubMed score by year
PubTator Score 1.19
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title