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Tbio
ACOT7
Cytosolic acyl coenzyme A thioester hydrolase

Protein Classes
Protein Summary
Description
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA. This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been cha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361521
  • ENSP00000354615
  • ENSG00000097021
  • ENST00000377842
  • ENSP00000367073
  • ENST00000377845
  • ENSP00000367076
  • ENST00000377855
  • ENSP00000367086
  • ENST00000377860
  • ENSP00000367091
  • ENST00000418124
  • ENSP00000402532
  • ENST00000545482
  • ENSP00000439218
  • ENST00000608083
  • ENSP00000476610

Symbol
  • BACH
  • ACT
  • ACH1
  • BACH
  • LACH
  • LACH1
  • hBACH
  • CTE-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.93
disease perturbation
0.9
transcription factor binding site profile
0.9
histone modification site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.55   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.55   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial Fatty Acid Beta-Oxidation
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Mitochondrial Fatty Acid Beta-Oxidation
Gene Ontology Terms (19)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (51)
1 – 10 of 51
CAB39L
Tbio
Novelty: 0.19600079
p_int: 0.999847438
p_ni: 0.000152562
Score: 0.534
Data Source: BioPlex,STRINGDB
CADPS
Tbio
Novelty: 0.03543392
p_int: 0.999794107
p_ni: 0.000205893
Data Source: BioPlex
BTRC
Tbio
Novelty: 0.00393331
p_int: 0.999407004
p_ni: 0.000592996
Data Source: BioPlex
DHRS4L2
Tbio
Family: Enzyme
Novelty: 0.02969109
p_int: 0.997620976
p_ni: 0.002379024
Score: 0.338
Data Source: BioPlex,STRINGDB
RELT
Tbio
Novelty: 0.01273037
p_int: 0.984333304
p_ni: 0.015666695
p_wrong: 1e-9
Score: 0.319
Data Source: BioPlex,STRINGDB
PKNOX1
Tbio
Family: TF
Novelty: 0.01712074
p_int: 0.952734607
p_ni: 0.047265393
Score: 0.239
Data Source: BioPlex,STRINGDB
RABGAP1L
Tbio
Family: Enzyme
Novelty: 0.369696
p_int: 0.847988645
p_ni: 0.152011355
Score: 0.205
Data Source: BioPlex,STRINGDB
FAM24B
Tdark
p_int: 0.76947962
p_ni: 0.23052038
Data Source: BioPlex
ACOT1
Tbio
Family: Enzyme
Novelty: 0.00725795
Score: 0.941
Data Source: STRINGDB
TECR
Tbio
Family: Enzyme
Novelty: 0.00220663
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  113.55

PubMed score by year
PubTator Score  344.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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