ACOT7
Cytosolic acyl coenzyme A thioester hydrolase
Protein Summary
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA. This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been cha ...more
- ENST00000361521
- ENSP00000354615
- ENSG00000097021
- ENST00000377842
- ENSP00000367073
- ENST00000377845
- ENSP00000367076
- ENST00000377855
- ENSP00000367086
- ENST00000377860
- ENSP00000367091
- ENST00000418124
- ENSP00000402532
- ENST00000545482
- ENSP00000439218
- ENST00000608083
- ENSP00000476610
- BACH
- ACT
- ACH1
- BACH
- LACH
- LACH1
- hBACH
- CTE-II
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.99 | ||
kinase perturbation | 0.93 | ||
disease perturbation | 0.9 | ||
transcription factor binding site profile | 0.9 | ||
histone modification site profile | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 114.07 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 150 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 114.07 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 150 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0