Tbio DDX39A ATP-dependent RNA helicase DDX39A

Protein Summary

Description

Isoform 1: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• O00148
• B1Q2N1
• Q8N5M0
• Q9BVP6
• Q9H5W0

Gene Name

• DDX39A

Ensembl ID

• ENST00000242776
• ENSP00000242776
• ENSG00000123136
• ENST00000324340
• ENSP00000322749
• ENST00000454233
• ENSP00000392929
• ENST00000588692
• ENSP00000467862

Symbol

• DDX39
• BAT1
• DDXL
• BAT1L
• DDX39
• URH49

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
interacting protein	0.97
kinase perturbation	0.96
molecular function	0.95
transcription factor binding site profile	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.69   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.69   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0