Tbio FZD9 Frizzled-9

Protein Summary

Description

Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00144
• Fz-9

Gene Name

• FZD9

Ensembl ID

• ENST00000344575
• ENSP00000345785
• ENSG00000188763

Symbol

• FZD3
• FZD3
• CD349

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.77
tissue	0.65
histone modification site profile	0.61
tissue sample	0.6
protein domain	0.58

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.06   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 500   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.06   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 500   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (85)

Explore Interacting Targets

1 – 10 of 85

• See Interactions on String-DB

WNT7A

Tbio

Novelty:  0.00421662

Score:  0.983

Data Source:  STRINGDB

WNT2

Tbio

Novelty:  0.00313614

Score:  0.981

Data Source:  STRINGDB

WNT1

Tbio

Novelty:  0.00124301

Score:  0.98

Data Source:  STRINGDB

WNT5A

Tbio

Novelty:  0.00125563

Score:  0.979

Data Source:  STRINGDB

WNT16

Tbio

Novelty:  0.00966869

Score:  0.974

Data Source:  STRINGDB

WNT3A

Tchem

Novelty:  0.00119275

Score:  0.974

Data Source:  STRINGDB

WNT3

Tchem

Novelty:  0.00498299

Score:  0.973

Data Source:  STRINGDB

WNT4

Tbio

Novelty:  0.00276803

Score:  0.972

Data Source:  STRINGDB

WNT2B

Tbio

Novelty:  0.00783711

Score:  0.972

Data Source:  STRINGDB

WNT7B

Tbio

Novelty:  0.00684526

Score:  0.971

Data Source:  STRINGDB

Pathways (56)

Reactome (4)

KEGG (13)

PathwayCommons (30)

WikiPathways (9)

Class B/2 (Secretin family receptors) (R-HSA-373080)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by GPCR	1212 targets	R-HSA-372790

Name	Explore in Pharos	Explore in Source
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
GPCR ligand binding	460 targets	R-HSA-500792
Signal Transduction	2704 targets	R-HSA-162582
Signaling by GPCR	1212 targets	R-HSA-372790

Gene Ontology Terms (39)

Functions (5)

Components (11)

Processes (23)

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GO Term	Evidence	Assigned by
protein heterodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
protein homodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
Wnt-protein binding	Inferred from Physical Interaction (IPI)	UniProtKB
Wnt-activated receptor activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
G protein-coupled receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

GWAS Traits (24)

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1 – 5 of 24

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	12	14	20		99.9
sleep duration	EFO_0005271	2	3	3		96.4
serum gamma-glutamyl transferase measurement	EFO_0004532	1	2	2		89.5
urate measurement	EFO_0004531	3	2	3		80.7
high density lipoprotein cholesterol measurement	EFO_0004612	3	3	4		80.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 24

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	20		99.9
sleep duration	EFO_0005271	3		96.4
serum gamma-glutamyl transferase measurement	EFO_0004532	2		89.5
urate measurement	EFO_0004531	3		80.7
high density lipoprotein cholesterol measurement	EFO_0004612	4		80.1

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UniProt Keyword Find Similar Targets

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Cell membrane
Complete proteome
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Signal

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein B measurement
appendicular lean mass
birth weight
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
body height
C-reactive protein measurement
diet measurement
HbA1c measurement
high density lipoprotein cholesterol measurement

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging
nervous system phenotype
skeleton phenotype

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	frizzled class receptor 9	VGNC:4363	472405
Mouse	frizzled class receptor 9	MGI:1313278	14371
Rat	frizzled class receptor 9	RGD:628817	266608
Dog	frizzled class receptor 9	VGNC:41035	489809
Cow	frizzled class receptor 9	VGNC:29172	521364

Species	Name	OMA	EggNOG	Inparanoid
Chimp	frizzled class receptor 9
Mouse	frizzled class receptor 9
Rat	frizzled class receptor 9
Dog	frizzled class receptor 9
Cow	frizzled class receptor 9

Publication Statistics

PubMed Score 68.06

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PubTator Score 30.81

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