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Tbio
FZD9
Frizzled-9

Protein Summary
Description
Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). Members of the 'frizzled' gene family encode 7-transmembr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344575
  • ENSP00000345785
  • ENSG00000188763

Symbol
  • FZD3
  • FZD3
  • CD349
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
tissue
0.65
histone modification site profile
0.61
tissue sample
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.06   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 500   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.06   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 500   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (85)
1 – 10 of 85
WNT7A
Tbio
Novelty:  0.00421662
Score:  0.983
Data Source:  STRINGDB
WNT2
Tbio
Novelty:  0.00313614
Score:  0.981
Data Source:  STRINGDB
WNT1
Tbio
Novelty:  0.00124301
Score:  0.98
Data Source:  STRINGDB
WNT5A
Tbio
Novelty:  0.00125563
Score:  0.979
Data Source:  STRINGDB
WNT16
Tbio
Novelty:  0.00966869
Score:  0.974
Data Source:  STRINGDB
WNT3A
Tchem
Novelty:  0.00119275
Score:  0.974
Data Source:  STRINGDB
WNT3
Tchem
Novelty:  0.00498299
Score:  0.973
Data Source:  STRINGDB
WNT4
Tbio
Novelty:  0.00276803
Score:  0.972
Data Source:  STRINGDB
WNT2B
Tbio
Novelty:  0.00783711
Score:  0.972
Data Source:  STRINGDB
WNT7B
Tbio
Novelty:  0.00684526
Score:  0.971
Data Source:  STRINGDB
Pathways (56)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (39)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
12
14
20
99.9
sleep duration
2
3
3
96.4
serum gamma-glutamyl transferase measurement
1
2
2
89.5
urate measurement
3
2
3
80.7
high density lipoprotein cholesterol measurement
3
3
4
80.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
20
99.9
sleep duration
3
96.4
serum gamma-glutamyl transferase measurement
2
89.5
urate measurement
3
80.7
high density lipoprotein cholesterol measurement
4
80.1
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 9
VGNC:4363
472405
Mouse
MGI:1313278
14371
Rat
RGD:628817
266608
Dog
frizzled class receptor 9
VGNC:41035
489809
Cow
frizzled class receptor 9
VGNC:29172
521364
Species
Name
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 9
Mouse
Rat
Dog
frizzled class receptor 9
Cow
frizzled class receptor 9
Publication Statistics
PubMed Score 68.06
PubMed score by year
PubTator Score 30.81
PubTator score by year
Patents
Patents by year