Protein Summary
Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). Members of the 'frizzled' gene family encode 7-transmembr ...more
- ENST00000344575
- ENSP00000345785
- ENSG00000188763
- FZD3
- FZD3
- CD349
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.77 | ||
tissue | 0.65 | ||
histone modification site profile | 0.61 | ||
tissue sample | 0.6 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.06 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 500 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.06 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 500 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (85)
Nearest Tclin Targets (9)
Upstream (7)
Downstream (2)
1 – 5 of 7
Pathways (56)
Reactome (4)
KEGG (13)
PathwayCommons (30)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Viral Interactions (0)
Gene Ontology Terms (39)
Functions (5)
Components (11)
Processes (23)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 12 | 14 | 20 | 99.9 | |||||
sleep duration | 2 | 3 | 3 | 96.4 | |||||
serum gamma-glutamyl transferase measurement | 1 | 2 | 2 | 89.5 | |||||
urate measurement | 3 | 2 | 3 | 80.7 | |||||
high density lipoprotein cholesterol measurement | 3 | 3 | 4 | 80.1 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 20 | 99.9 | |||||
sleep duration | 3 | 96.4 | |||||
serum gamma-glutamyl transferase measurement | 2 | 89.5 | |||||
urate measurement | 3 | 80.7 | |||||
high density lipoprotein cholesterol measurement | 4 | 80.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | frizzled class receptor 9 | VGNC:4363 | 472405 | |||||
Mouse | MGI:1313278 | 14371 | ||||||
Rat | RGD:628817 | 266608 | ||||||
Dog | frizzled class receptor 9 | VGNC:41035 | 489809 | |||||
Cow | frizzled class receptor 9 | VGNC:29172 | 521364 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | frizzled class receptor 9 | |||||
Mouse | ||||||
Rat | ||||||
Dog | frizzled class receptor 9 | |||||
Cow | frizzled class receptor 9 | |||||
Publication Statistics
PubMed Score 68.06
PubMed score by year
PubTator Score 30.81
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (24)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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