Tchem TK2 Thymidine kinase 2, mitochondrial

Protein Summary

Description

Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents. This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• O00142
• B4DGJ7
• B4DZK7
• B7ZAB1
• E5KNQ5
• E9PH08
• O15238

Gene Name

• TK2

Ensembl ID

• ENST00000299697
• ENSP00000299697
• ENSG00000166548
• ENST00000451102
• ENSP00000414334
• ENST00000525974
• ENSP00000434594
• ENST00000527284
• ENSP00000435312
• ENST00000527800
• ENSP00000433770
• ENST00000544898
• ENSP00000440898
• ENST00000545043
• ENSP00000438143
• ENST00000563369
• ENSP00000463560
• ENST00000620035
• ENSP00000483833

Symbol

• MTTK
• PEOB3
• SCA31
• MTDPS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
disease perturbation	0.83
kinase perturbation	0.76
transcription factor binding site profile	0.76
virus perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Nucleotide Kinase / Thymidine Kinase 2, Mitochondrial

DTO Classes

Protein / Kinase / Non-protein Kinase / Nucleoside Kinase / Dck/dgk Family / Thymidine Kinase 2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.11   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 65   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.11   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0