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Tchem
TK2
Thymidine kinase 2, mitochondrial

Protein Summary
Description
Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents. This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299697
  • ENSP00000299697
  • ENSG00000166548
  • ENST00000451102
  • ENSP00000414334
  • ENST00000525974
  • ENSP00000434594
  • ENST00000527284
  • ENSP00000435312
  • ENST00000527800
  • ENSP00000433770
  • ENST00000544898
  • ENSP00000440898
  • ENST00000545043
  • ENSP00000438143
  • ENST00000563369
  • ENSP00000463560
  • ENST00000620035
  • ENSP00000483833

Symbol
  • MTTK
  • PEOB3
  • SCA31
  • MTDPS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
disease perturbation
0.83
kinase perturbation
0.76
transcription factor binding site profile
0.76
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.9   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.9   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL1091988
chemical structure image
Pathways (12)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Pyrimidine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Pyrimidine salvage
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (76)
1 – 10 of 76
DKK1
Tchem
Novelty: 0.00143301
p_int: 0.999999941
p_ni: 1.5e-8
p_wrong: 4.4e-8
Score: 0.516
Data Source: BioPlex,STRINGDB
CTNNBIP1
Tbio
Novelty: 0.08527893
p_int: 0.999999938
p_ni: 6.1e-8
p_wrong: 1e-9
Score: 0.309
Data Source: BioPlex,STRINGDB
GSTK1
Tchem
Family: Enzyme
Novelty: 0.06692867
p_int: 0.999999719
p_ni: 2.79e-7
p_wrong: 2e-9
Score: 0.275
Data Source: BioPlex,STRINGDB
DUT
Tchem
Family: Enzyme
Novelty: 0.003979
Score: 0.975
Data Source: STRINGDB
TYMP
Tclin
Family: Enzyme
Novelty: 0.00150895
Score: 0.958
Data Source: STRINGDB
TYMS
Tclin
Family: Enzyme
Novelty: 0.00104333
Score: 0.958
Data Source: STRINGDB
DTYMK
Tbio
Family: Kinase
Novelty: 0.00943201
Score: 0.943
Data Source: STRINGDB
UPP1
Tchem
Family: Enzyme
Novelty: 0.01749136
Score: 0.938
Data Source: STRINGDB
UPP2
Tbio
Family: Enzyme
Novelty: 0.0630063
Score: 0.932
Data Source: STRINGDB
DCTD
Tbio
Family: Enzyme
Novelty: 0.02253182
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.90

PubMed score by year
PubTator Score  122.19

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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