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Tchem
TK2
Thymidine kinase 2, mitochondrial

Protein Summary
Description
Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents. This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299697
  • ENSP00000299697
  • ENSG00000166548
  • ENST00000451102
  • ENSP00000414334
  • ENST00000525974
  • ENSP00000434594
  • ENST00000527284
  • ENSP00000435312
  • ENST00000527800
  • ENSP00000433770
  • ENST00000544898
  • ENSP00000440898
  • ENST00000545043
  • ENSP00000438143
  • ENST00000563369
  • ENSP00000463560
  • ENST00000620035
  • ENSP00000483833

Symbol
  • MTTK
  • PEOB3
  • SCA31
  • MTDPS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
disease perturbation
0.83
kinase perturbation
0.76
transcription factor binding site profile
0.76
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.34   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.34   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (76)
DKK1
Tchem
Novelty:  0.00117121
p_int:  0.999999941
p_ni:  1.5e-8
p_wrong:  4.4e-8
Score:  0.516
Data Source:  BioPlex,STRINGDB
CTNNBIP1
Tbio
Novelty:  0.05434645
p_int:  0.999999938
p_ni:  6.1e-8
p_wrong:  1e-9
Score:  0.309
Data Source:  BioPlex,STRINGDB
GSTK1
Tchem
Family:  Enzyme
Novelty:  0.04205366
p_int:  0.999999719
p_ni:  2.79e-7
p_wrong:  2e-9
Score:  0.275
Data Source:  BioPlex,STRINGDB
DUT
Tchem
Family:  Enzyme
Novelty:  0.0026993
Score:  0.975
Data Source:  STRINGDB
TYMP
Tclin
Family:  Enzyme
Novelty:  0.0015906
Score:  0.958
Data Source:  STRINGDB
TYMS
Tclin
Family:  Enzyme
Novelty:  0.00087522
Score:  0.958
Data Source:  STRINGDB
DTYMK
Tbio
Family:  Kinase
Novelty:  0.00746576
Score:  0.943
Data Source:  STRINGDB
UPP1
Tchem
Family:  Enzyme
Novelty:  0.01384975
Score:  0.938
Data Source:  STRINGDB
UPP2
Tbio
Family:  Enzyme
Novelty:  0.03788751
Score:  0.932
Data Source:  STRINGDB
DCTD
Tbio
Family:  Enzyme
Novelty:  0.02275597
Score:  0.931
Data Source:  STRINGDB
Pathways (12)
Metabolism (R-HSA-1430728)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Pyrimidine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Pyrimidine salvage
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
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IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
thymidine kinase 2, mitochondrial
693544
Mouse
MGI:1913266
57813
Rat
RGD:1309279
291824
Dog
thymidine kinase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:11831]
Horse
thymidine kinase 2, mitochondrial
100065312
Species
Name
OMA
EggNOG
Inparanoid
Macaque
thymidine kinase 2, mitochondrial
Mouse
Rat
Dog
thymidine kinase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:11831]
Horse
thymidine kinase 2, mitochondrial
Publication Statistics
PubMed Score 9.34
PubMed score by year
PubTator Score 122.19
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Text