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Tchem
SGK1
Serine/threonine-protein kinase Sgk1

Protein Summary
Description
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237305
  • ENSP00000237305
  • ENSG00000118515
  • ENST00000367857
  • ENSP00000356831
  • ENST00000367858
  • ENSP00000356832
  • ENST00000413996
  • ENSP00000396242
  • ENST00000528577
  • ENSP00000434450

Symbol
  • SGK
  • SGK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
molecular function
0.98
biological term
0.97
small molecule perturbation
0.97
transcription factor perturbation
0.97


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 765.49   (req: < 5)
Gene RIFs: 182   (req: <= 3)
Antibodies: 821   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 765.49   (req: >= 5)
Gene RIFs: 182   (req: > 3)
Antibodies: 821   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 53
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (185)
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.967598725
p_ni:  0.032401275
Score:  0.665
Data Source:  BioPlex,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
p_int:  0.944512127
p_ni:  0.04285321
p_wrong:  0.012634663
Score:  0.591
Data Source:  BioPlex,STRINGDB
ARL5B
Tbio
Family:  Enzyme
Novelty:  0.03703395
p_int:  0.799670615
p_ni:  0.200322764
p_wrong:  0.000006621
Score:  0.312
Data Source:  BioPlex,STRINGDB
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
Score:  0.995
Data Source:  Reactome,STRINGDB
RICTOR
Tbio
Novelty:  0.00250734
Score:  0.994
Data Source:  STRINGDB
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
Score:  0.993
Data Source:  Reactome,STRINGDB
FOXO3
Tbio
Family:  TF
Novelty:  0.00074316
Score:  0.992
Data Source:  STRINGDB
MLST8
Tbio
Novelty:  0.00423122
Score:  0.979
Data Source:  STRINGDB
TSC22D3
Tbio
Family:  TF
Novelty:  0.00660285
Score:  0.978
Data Source:  Reactome,STRINGDB
MAPKAP1
Tbio
Novelty:  0.01301743
Score:  0.977
Data Source:  STRINGDB
Pathways (27)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Ion channel transport
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Ion channel transport
RNA Polymerase II Transcription
Regulation of TP53 Activity
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
1
1
2
82.8
calcium measurement
1
1
1
80.4
factor VIII measurement
1
1
1
64.4
monocyte count
1
1
1
40.7
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
2
82.8
calcium measurement
1
80.4
factor VIII measurement
1
64.4
monocyte count
1
40.7
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serum/glucocorticoid regulated kinase 1
VGNC:11250
463011
Macaque
serum/glucocorticoid regulated kinase 1
713082
Mouse
MGI:1340062
20393
Rat
RGD:3668
29517
Dog
serum/glucocorticoid regulated kinase 1
VGNC:46097
403647
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serum/glucocorticoid regulated kinase 1
Macaque
serum/glucocorticoid regulated kinase 1
Mouse
Rat
Dog
serum/glucocorticoid regulated kinase 1
Publication Statistics
PubMed Score 765.49
PubMed score by year
PubTator Score 303.90
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title