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Tbio
KIF2A
Kinesin-like protein KIF2A

Protein Summary
Description
Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381103
  • ENSP00000370493
  • ENSG00000068796
  • ENST00000401507
  • ENSP00000385622
  • ENST00000407818
  • ENSP00000385000
  • ENST00000506857
  • ENSP00000423772

Symbol
  • KIF2
  • KNS2
  • HK2
  • KIF2
  • CDCBM3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
disease perturbation
0.93
virus perturbation
0.88
transcription factor perturbation
0.84
transcription factor binding site profile
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.24   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.24   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
84.1
mean corpuscular volume
1
1
1
20.5
mean reticulocyte volume
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
84.1
mean corpuscular volume
1
20.5
mean reticulocyte volume
1
17.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 2A
VGNC:13529
100615381
Macaque
kinesin family member 2A
696561
Mouse
MGI:108390
16563
Rat
RGD:70974
84391
Dog
kinesin family member 2A
VGNC:42402
478071
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 2A
Macaque
kinesin family member 2A
Mouse
Rat
Dog
kinesin family member 2A
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (28)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
COPI-dependent Golgi-to-ER retrograde traffic
Cell Cycle
Gene Ontology Terms (29)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (294)
1 – 10 of 294
TSNAX
Tbio
Novelty: 0.00888891
p_int: 1
Score: 0.612
Data Source: BioPlex,STRINGDB
TYW3
Tdark
Novelty: 0.15183348
p_int: 0.9999996
p_ni: 4e-7
Score: 0.161
Data Source: BioPlex,STRINGDB
RHPN1
Tbio
Novelty: 0.05722992
p_int: 0.999829311
p_ni: 0.000170643
p_wrong: 4.6e-8
Score: 0.184
Data Source: BioPlex,STRINGDB
KBTBD7
Tdark
Novelty: 0.4947466
p_int: 0.996973263
p_ni: 0.003026737
Data Source: BioPlex
RPS13
Tbio
Novelty: 0.0019983
p_int: 0.994692397
p_ni: 0.00530744
p_wrong: 1.62e-7
Data Source: BioPlex
FGB
Tbio
Novelty: 0.00437751
p_int: 0.967599255
p_ni: 0.032399818
p_wrong: 9.27e-7
Data Source: BioPlex
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
Score: 0.984
Data Source: STRINGDB
AURKB
Tchem
Family: Kinase
Novelty: 0.00100972
Score: 0.979
Data Source: STRINGDB
CKAP5
Tbio
Novelty: 0.00623771
Score: 0.973
Data Source: STRINGDB
NDC80
Tbio
Novelty: 0.00331814
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  77.24

PubMed score by year
PubTator Score  104.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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