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Tbio
AGPS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

Protein Summary
Description
Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids. This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264167
  • ENSP00000264167
  • ENSG00000018510

Symbol
  • ADAS
  • ADPS
  • RCDP3
  • ADAP-S
  • ADHAPS
  • ALDHPSY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
protein domain
0.92
drug perturbation
0.87
cellular component
0.84
transcription factor binding site profile
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.58   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.58   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
GNPAT
Tchem
Family:  Enzyme
Novelty:  0.01255689
Score:  0.993
Data Source:  Reactome,STRINGDB
TYSND1
Tbio
Family:  Enzyme
Novelty:  0.16036122
Score:  0.963
Data Source:  Reactome,STRINGDB
PEX7
Tbio
Novelty:  0.01487923
Score:  0.962
Data Source:  Reactome,STRINGDB
PHYH
Tbio
Family:  Enzyme
Novelty:  0.00277669
Score:  0.948
Data Source:  STRINGDB
PEX14
Tbio
Novelty:  0.0210557
Score:  0.947
Data Source:  Reactome,STRINGDB
ACAA1
Tbio
Family:  Enzyme
Novelty:  0.00710465
Score:  0.939
Data Source:  STRINGDB
PEX12
Tbio
Novelty:  0.02252744
Score:  0.933
Data Source:  Reactome,STRINGDB
PEX10
Tbio
Novelty:  0.0174463
Score:  0.93
Data Source:  Reactome,STRINGDB
PEX13
Tbio
Novelty:  0.01777214
Score:  0.925
Data Source:  Reactome,STRINGDB
PEX2
Tbio
Novelty:  0.01015599
Score:  0.916
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal protein import
Reactome
Plasmalogen biosynthesis
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Peroxisomal protein import
Plasmalogen biosynthesis
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
56.2
C-reactive protein measurement
1
1
1
50.6
sex hormone-binding globulin measurement
2
1
2
42.3
testosterone measurement
1
1
1
36.9
alcohol consumption measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
56.2
C-reactive protein measurement
1
50.6
sex hormone-binding globulin measurement
2
42.3
testosterone measurement
1
36.9
alcohol consumption measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alkylglycerone phosphate synthase
VGNC:50326
740316
Macaque
alkylglycerone phosphate synthase
702139
Mouse
MGI:2443065
228061
Rat
RGD:620364
84114
Dog
alkylglycerone phosphate synthase
VGNC:37714
488421
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alkylglycerone phosphate synthase
Macaque
alkylglycerone phosphate synthase
Mouse
Rat
Dog
alkylglycerone phosphate synthase
Publication Statistics
PubMed Score 96.58
PubMed score by year
PubTator Score 732.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title