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Tbio
AGPS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

Protein Summary
Description
Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids. This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264167
  • ENSP00000264167
  • ENSG00000018510

Symbol
  • ADAS
  • ADPS
  • RCDP3
  • ADAP-S
  • ADHAPS
  • ALDHPSY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
protein domain
0.92
drug perturbation
0.87
cellular component
0.84
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.78   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.78   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
77.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
77.4
Pathways (17)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal protein import
Reactome
Plasmalogen biosynthesis
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Peroxisomal protein import
Plasmalogen biosynthesis
Protein localization
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (79)
1 – 10 of 79
GNPAT
Tchem
Family: Enzyme
Novelty: 0.01255689
Score: 0.993
Data Source: Reactome,STRINGDB
TYSND1
Tbio
Family: Enzyme
Novelty: 0.16036122
Score: 0.963
Data Source: Reactome,STRINGDB
PEX7
Tbio
Novelty: 0.01487923
Score: 0.962
Data Source: Reactome,STRINGDB
PHYH
Tbio
Family: Enzyme
Novelty: 0.00277669
Score: 0.948
Data Source: STRINGDB
PEX14
Tbio
Novelty: 0.0210557
Score: 0.947
Data Source: Reactome,STRINGDB
ACAA1
Tbio
Family: Enzyme
Novelty: 0.00710465
Score: 0.939
Data Source: STRINGDB
PEX12
Tbio
Novelty: 0.02252744
Score: 0.933
Data Source: Reactome,STRINGDB
PEX10
Tbio
Novelty: 0.0174463
Score: 0.93
Data Source: Reactome,STRINGDB
PEX13
Tbio
Novelty: 0.01777214
Score: 0.925
Data Source: Reactome,STRINGDB
PEX2
Tbio
Novelty: 0.01015599
Score: 0.916
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  91.78

PubMed score by year
PubTator Score  732.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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