Protein Summary
The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq, Oct 2008]
- ENST00000342595
- ENSP00000340328
- ENSG00000188937
- ENST00000378220
- ENSP00000367465
- CLRP
- CLRP
- NBM1
- CSNB1
- CSNB4
- CSNB1A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.66 | ||
protein domain | 0.58 | ||
tissue | 0.55 | ||
cell line | 0.44 | ||
biological term | 0.42 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 103.19 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 91 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 103.19 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 91 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (60)
LYPLA2
Family: Enzyme
Novelty: 0.05436006
p_int: 0.999727856
p_ni: 0.000272078
p_wrong: 6.6e-8
Score: 0.217
Data Source: BioPlex,STRINGDB
SHROOM1
Novelty: 0.27291256
p_int: 0.999702108
p_ni: 0.000142935
p_wrong: 0.000154958
Score: 0.54
Data Source: BioPlex,STRINGDB
STPG2
Novelty: 0.62741225
p_int: 0.9933665
p_ni: 0.006012348
p_wrong: 0.000621152
Score: 0.315
Data Source: BioPlex,STRINGDB
EMB
Novelty: 0.00135577
p_int: 0.988265422
p_ni: 0.010051154
p_wrong: 0.001683424
Score: 0.189
Data Source: BioPlex,STRINGDB
COX16
Family: Enzyme
Novelty: 0.20901823
p_int: 0.892198811
p_ni: 0.104346553
p_wrong: 0.003454636
Score: 0.309
Data Source: BioPlex,STRINGDB
CNPY3
Novelty: 0.11473132
p_int: 0.794456388
p_ni: 0.205543607
p_wrong: 5e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
SPRYD7
Novelty: 0.25334319
p_int: 0.786174886
p_ni: 0.00001344
p_wrong: 0.213811674
Score: 0.224
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (5)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | nyctalopin | VGNC:1351 | 473571 | |||||
Macaque | nyctalopin | 700641 | ||||||
Mouse | MGI:2448607 | 236690 | ||||||
Rat | RGD:1561300 | 302516 | ||||||
Dog | nyctalopin | VGNC:44084 | 491837 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | nyctalopin | |||||
Macaque | nyctalopin | |||||
Mouse | ||||||
Rat | ||||||
Dog | nyctalopin | |||||
Publication Statistics
PubMed Score 103.19
PubMed score by year
PubTator Score 87.14
PubTator score by year
Related Publications
Text Mined References (26)
GeneRif Annotations (20)
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