Tbio NYX Nyctalopin

Protein Summary

Description

The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q9GZU5
• D3DWC0
• Q2M1S4
• Q5H983
• Q9H4J0

Gene Name

• NYX

Ensembl ID

• ENST00000342595
• ENSP00000340328
• ENSG00000188937
• ENST00000378220
• ENSP00000367465

Symbol

• CLRP
• CLRP
• NBM1
• CSNB1
• CSNB4
• CSNB1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.66
protein domain	0.58
tissue	0.55
cell line	0.44
biological term	0.42

Protein Classes

PANTHER Classes

Protein / Receptor / Nyctalopin

Protein / Extracellular Matrix Protein / Nyctalopin

DTO Classes

Protein / Receptor / Nyctalopin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.19   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.19   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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ProtVista Viewer

Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (60)

Explore Interacting Targets

1 – 10 of 60

• See Interactions on String-DB

LYPLA2

Tchem

Family:  Enzyme

Novelty:  0.05436006

p_int:  0.999727856

p_ni:  0.000272078

p_wrong:  6.6e-8

Score:  0.217

Data Source:  BioPlex,STRINGDB

SHROOM1

Tdark

Novelty:  0.27291256

p_int:  0.999702108

p_ni:  0.000142935

p_wrong:  0.000154958

Score:  0.54

Data Source:  BioPlex,STRINGDB

STPG2

Tdark

Novelty:  0.62741225

p_int:  0.9933665

p_ni:  0.006012348

p_wrong:  0.000621152

Score:  0.315

Data Source:  BioPlex,STRINGDB

EMB

Tbio

Novelty:  0.00135577

p_int:  0.988265422

p_ni:  0.010051154

p_wrong:  0.001683424

Score:  0.189

Data Source:  BioPlex,STRINGDB

COX16

Tbio

Family:  Enzyme

Novelty:  0.20901823

p_int:  0.892198811

p_ni:  0.104346553

p_wrong:  0.003454636

Score:  0.309

Data Source:  BioPlex,STRINGDB

TUBA4A

Tchem

Novelty:  0.00820546

p_int:  0.849139378

p_ni:  0.150860622

Data Source:  BioPlex

CNPY3

Tbio

Novelty:  0.11473132

p_int:  0.794456388

p_ni:  0.205543607

p_wrong:  5e-9

Score:  0.189

Data Source:  BioPlex,STRINGDB

SPRYD7

Tdark

Novelty:  0.25334319

p_int:  0.786174886

p_ni:  0.00001344

p_wrong:  0.213811674

Score:  0.224

Data Source:  BioPlex,STRINGDB

TRPM1

Tchem

Family:  IC

Novelty:  0.00822899

Score:  0.812

Data Source:  STRINGDB

CACNA1F

Tchem

Family:  IC

Novelty:  0.00431963

Score:  0.808

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Components (3)

Processes (2)

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1 – 3 of 3

GO Term	Evidence	Assigned by
intracellular	Inferred from Direct Assay (IDA)	UniProtKB
extracellular matrix	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
extracellular space	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Congenital stationary night blindness
Disease mutation
Extracellular matrix
Glycoprotein
Leucine-rich repeat
Polymorphism
Proteoglycan
Reference proteome
Repeat

MGI Phenotype Find Similar Targets

No Header	No Header
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nyctalopin	VGNC:1351	473571
Macaque	nyctalopin		700641
Mouse	nyctalopin	MGI:2448607	236690
Rat	nyctalopin	RGD:1561300	302516
Dog	nyctalopin	VGNC:44084	491837

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nyctalopin
Macaque	nyctalopin
Mouse	nyctalopin
Rat	nyctalopin
Dog	nyctalopin

Publication Statistics

PubMed Score 103.19

PubMed score by year

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PubTator Score 87.14

PubTator score by year

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Related Publications

Text Mined References (26)

GeneRif Annotations (20)

Items per page:

10

0 of 0

PMID	Year	Title