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Tbio
NYX
Nyctalopin

Protein Summary
Description
The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342595
  • ENSP00000340328
  • ENSG00000188937
  • ENST00000378220
  • ENSP00000367465

Symbol
  • CLRP
  • CLRP
  • NBM1
  • CSNB1
  • CSNB4
  • CSNB1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.66
protein domain
0.58
tissue
0.55
cell line
0.44
biological term
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.19   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.19   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
LYPLA2
Tchem
Family:  Enzyme
Novelty:  0.05436006
p_int:  0.999727856
p_ni:  0.000272078
p_wrong:  6.6e-8
Score:  0.217
Data Source:  BioPlex,STRINGDB
SHROOM1
Tdark
Novelty:  0.27291256
p_int:  0.999702108
p_ni:  0.000142935
p_wrong:  0.000154958
Score:  0.54
Data Source:  BioPlex,STRINGDB
STPG2
Tdark
Novelty:  0.62741225
p_int:  0.9933665
p_ni:  0.006012348
p_wrong:  0.000621152
Score:  0.315
Data Source:  BioPlex,STRINGDB
EMB
Tbio
Novelty:  0.00135577
p_int:  0.988265422
p_ni:  0.010051154
p_wrong:  0.001683424
Score:  0.189
Data Source:  BioPlex,STRINGDB
COX16
Tbio
Family:  Enzyme
Novelty:  0.20901823
p_int:  0.892198811
p_ni:  0.104346553
p_wrong:  0.003454636
Score:  0.309
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.849139378
p_ni:  0.150860622
Data Source:  BioPlex
CNPY3
Tbio
Novelty:  0.11473132
p_int:  0.794456388
p_ni:  0.205543607
p_wrong:  5e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
SPRYD7
Tdark
Novelty:  0.25334319
p_int:  0.786174886
p_ni:  0.00001344
p_wrong:  0.213811674
Score:  0.224
Data Source:  BioPlex,STRINGDB
TRPM1
Tchem
Family:  IC
Novelty:  0.00822899
Score:  0.812
Data Source:  STRINGDB
CACNA1F
Tchem
Family:  IC
Novelty:  0.00431963
Score:  0.808
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nyctalopin
VGNC:1351
473571
Macaque
nyctalopin
700641
Mouse
MGI:2448607
236690
Rat
RGD:1561300
302516
Dog
nyctalopin
VGNC:44084
491837
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nyctalopin
Macaque
nyctalopin
Mouse
Rat
Dog
nyctalopin
Publication Statistics
PubMed Score 103.19
PubMed score by year
PubTator Score 87.14
PubTator score by year
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Related Publications
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PMID
Year
Title