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Tdark
NXPH3
Neurexophilin-3

Protein Summary
Description
May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328741
  • ENSP00000329295
  • ENSG00000182575

Symbol
  • KIAA1159
  • NPH3
  • NPH3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
tissue sample
0.68
kinase perturbation
0.66
transcription factor binding site profile
0.66
microRNA
0.62


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.28   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.28   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
SUFU
Tbio
Novelty:  0.00475249
p_int:  0.999993637
p_ni:  0.000006363
Score:  0.163
Data Source:  BioPlex,STRINGDB
PALD1
Tbio
Novelty:  0.0248863
p_int:  0.99732601
p_ni:  0.00256381
p_wrong:  0.000110181
Score:  0.313
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.962725749
p_ni:  0.037274251
Data Source:  BioPlex
DCP2
Tbio
Family:  Enzyme
Novelty:  0.00661786
p_int:  0.90442797
p_ni:  0.002665323
p_wrong:  0.092906706
Score:  0.189
Data Source:  BioPlex,STRINGDB
TUBA1A
Tchem
Novelty:  0.01030145
p_int:  0.771958397
p_ni:  0.228041603
Score:  0.509
Data Source:  BioPlex,STRINGDB
P58400
Tbio
Novelty:  0.00454659
Score:  0.856
Data Source:  STRINGDB
Q9ULB1
Tbio
Novelty:  0.00454659
Score:  0.856
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.715
Data Source:  STRINGDB
ECEL1
Tbio
Family:  Enzyme
Novelty:  0.01488521
Score:  0.647
Data Source:  STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
Score:  0.619
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
33.1
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neurexophilin 3
574173
Mouse
MGI:1336188
104079
Rat
RGD:620693
59315
Dog
neurexophilin 3
VGNC:44079
612866
Horse
neurexophilin 3 [Source:HGNC Symbol;Acc:HGNC:8077]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neurexophilin 3
Mouse
Rat
Dog
neurexophilin 3
Horse
neurexophilin 3 [Source:HGNC Symbol;Acc:HGNC:8077]
Publication Statistics
PubMed Score 3.28
PubMed score by year
PubTator Score 10.28
PubTator score by year
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Related Publications
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PMID
Year
Title