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Tdark
NXPE3
NXPE family member 3

Protein Summary
Description
This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273347
  • ENSP00000273347
  • ENSG00000144815
  • ENST00000477909
  • ENSP00000418369
  • ENST00000491511
  • ENSP00000417485

Symbol
  • FAM55C
  • FAM55C
  • MST115
  • MSTP115
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
transcription factor perturbation
0.88
kinase perturbation
0.84
histone modification site profile
0.72
microRNA
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.72   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.72   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.999923782
p_ni:  0.000076218
Data Source:  BioPlex
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.999427312
p_ni:  0.000568913
p_wrong:  0.000003775
Data Source:  BioPlex
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.998688983
p_ni:  0.001311009
p_wrong:  8e-9
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.998058323
p_ni:  0.001941677
Data Source:  BioPlex
OS9
Tbio
Novelty:  0.01490339
p_int:  0.997575518
p_ni:  0.002424475
p_wrong:  7e-9
Data Source:  BioPlex
SYT12
Tbio
Novelty:  0.03410873
p_int:  0.996838439
p_ni:  0.003161533
p_wrong:  2.8e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.996493615
p_ni:  0.003506377
p_wrong:  8e-9
Data Source:  BioPlex
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.996442437
p_ni:  0.002936849
p_wrong:  0.000620713
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.991763292
p_ni:  0.008235557
p_wrong:  0.000001151
Data Source:  BioPlex
CRP
Tbio
Novelty:  0.00001517
p_int:  0.984971779
p_ni:  0.013898601
p_wrong:  0.00112962
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurexophilin and PC-esterase domain family member 3
VGNC:8842
740620
Macaque
neurexophilin and PC-esterase domain family member 3
702612
Mouse
MGI:2686598
385658
Rat
RGD:1584648
681096
Dog
neurexophilin and PC-esterase domain family member 3
VGNC:44075
478548
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurexophilin and PC-esterase domain family member 3
Macaque
neurexophilin and PC-esterase domain family member 3
Mouse
Rat
Dog
neurexophilin and PC-esterase domain family member 3
Publication Statistics
PubMed Score 0.72
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
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PMID
Year
Title