Protein Summary
This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
- ENST00000273347
- ENSP00000273347
- ENSG00000144815
- ENST00000477909
- ENSP00000418369
- ENST00000491511
- ENSP00000417485
- FAM55C
- FAM55C
- MST115
- MSTP115
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 0.98 | ||
transcription factor perturbation | 0.88 | ||
kinase perturbation | 0.84 | ||
histone modification site profile | 0.72 | ||
microRNA | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.72 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 38 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.72 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 38 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (39)
TCTN2
Novelty: 0.11617528
p_int: 0.999427312
p_ni: 0.000568913
p_wrong: 0.000003775
Data Source: BioPlex
HLA-DRA
Novelty: 0.0060214
p_int: 0.998688983
p_ni: 0.001311009
p_wrong: 8e-9
Data Source: BioPlex
MPPE1
Family: Enzyme
Novelty: 0.16027847
p_int: 0.998058323
p_ni: 0.001941677
Data Source: BioPlex
SYT12
Novelty: 0.03410873
p_int: 0.996838439
p_ni: 0.003161533
p_wrong: 2.8e-8
Score: 0.19
Data Source: BioPlex,STRINGDB
SCGB2A1
Novelty: 0.01902973
p_int: 0.996493615
p_ni: 0.003506377
p_wrong: 8e-9
Data Source: BioPlex
CLEC2D
Novelty: 0.02501194
p_int: 0.996442437
p_ni: 0.002936849
p_wrong: 0.000620713
Data Source: BioPlex
HFE
Novelty: 0.00042077
p_int: 0.991763292
p_ni: 0.008235557
p_wrong: 0.000001151
Data Source: BioPlex
CRP
Novelty: 0.00001517
p_int: 0.984971779
p_ni: 0.013898601
p_wrong: 0.00112962
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (1)
Components (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | neurexophilin and PC-esterase domain family member 3 | VGNC:8842 | 740620 | |||||
Macaque | neurexophilin and PC-esterase domain family member 3 | 702612 | ||||||
Mouse | MGI:2686598 | 385658 | ||||||
Rat | RGD:1584648 | 681096 | ||||||
Dog | neurexophilin and PC-esterase domain family member 3 | VGNC:44075 | 478548 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | neurexophilin and PC-esterase domain family member 3 | |||||
Macaque | neurexophilin and PC-esterase domain family member 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | neurexophilin and PC-esterase domain family member 3 | |||||
Publication Statistics
PubMed Score 0.72
PubMed score by year
PubTator Score 1.00
PubTator score by year
Related Publications
Text Mined References (8)
Items per page:
0 of 0
PMID | Year | Title |
---|