Tdark NXPE3 NXPE family member 3

Protein Summary

Description

This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Uniprot Accession IDs

• Q969Y0
• A8K0X4
• D3DN53
• Q7Z2S8

Gene Name

• NXPE3

Ensembl ID

• ENST00000273347
• ENSP00000273347
• ENSG00000144815
• ENST00000477909
• ENSP00000418369
• ENST00000491511
• ENSP00000417485

Symbol

• FAM55C
• FAM55C
• MST115
• MSTP115

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.98
transcription factor perturbation	0.88
kinase perturbation	0.84
histone modification site profile	0.72
microRNA	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.72   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 38   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.72   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (39)

Explore Interacting Targets

1 – 10 of 39

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SCGB2A2

Tbio

Novelty:  0.01594053

p_int:  0.999923782

p_ni:  0.000076218

Data Source:  BioPlex

TCTN2

Tbio

Novelty:  0.11617528

p_int:  0.999427312

p_ni:  0.000568913

p_wrong:  0.000003775

Data Source:  BioPlex

HLA-DRA

Tbio

Novelty:  0.0060214

p_int:  0.998688983

p_ni:  0.001311009

p_wrong:  8e-9

Data Source:  BioPlex

MPPE1

Tbio

Family:  Enzyme

Novelty:  0.16027847

p_int:  0.998058323

p_ni:  0.001941677

Data Source:  BioPlex

OS9

Tbio

Novelty:  0.01490339

p_int:  0.997575518

p_ni:  0.002424475

p_wrong:  7e-9

Data Source:  BioPlex

SYT12

Tbio

Novelty:  0.03410873

p_int:  0.996838439

p_ni:  0.003161533

p_wrong:  2.8e-8

Score:  0.19

Data Source:  BioPlex,STRINGDB

SCGB2A1

Tbio

Novelty:  0.01902973

p_int:  0.996493615

p_ni:  0.003506377

p_wrong:  8e-9

Data Source:  BioPlex

CLEC2D

Tbio

Novelty:  0.02501194

p_int:  0.996442437

p_ni:  0.002936849

p_wrong:  0.000620713

Data Source:  BioPlex

HFE

Tbio

Novelty:  0.00042077

p_int:  0.991763292

p_ni:  0.008235557

p_wrong:  0.000001151

Data Source:  BioPlex

CRP

Tbio

Novelty:  0.00001517

p_int:  0.984971779

p_ni:  0.013898601

p_wrong:  0.00112962

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Components (1)

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GO Term	Evidence	Assigned by
extracellular region	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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Complete proteome
Glycoprotein
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Reference proteome
Secreted
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IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	neurexophilin and PC-esterase domain family member 3	VGNC:8842	740620
Macaque	neurexophilin and PC-esterase domain family member 3		702612
Mouse	neurexophilin and PC-esterase domain family, member 3	MGI:2686598	385658
Rat	neurexophilin and PC-esterase domain family, member 3	RGD:1584648	681096
Dog	neurexophilin and PC-esterase domain family member 3	VGNC:44075	478548

Species	Name	OMA	EggNOG	Inparanoid
Chimp	neurexophilin and PC-esterase domain family member 3
Macaque	neurexophilin and PC-esterase domain family member 3
Mouse	neurexophilin and PC-esterase domain family, member 3
Rat	neurexophilin and PC-esterase domain family, member 3
Dog	neurexophilin and PC-esterase domain family member 3

Publication Statistics

PubMed Score 0.72

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PubTator Score 1.00

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Related Publications

Text Mined References (8)

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PMID	Year	Title