Tdark NXPE3 NXPE family member 3

Protein Summary

Description

This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Uniprot Accession IDs

• Q969Y0
• A8K0X4
• D3DN53
• Q7Z2S8

Gene Name

• NXPE3

Ensembl ID

• ENST00000273347
• ENSP00000273347
• ENSG00000144815
• ENST00000477909
• ENSP00000418369
• ENST00000491511
• ENSP00000417485

Symbol

• FAM55C
• FAM55C
• MST115
• MSTP115

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.98
transcription factor perturbation	0.88
kinase perturbation	0.84
histone modification site profile	0.72
microRNA	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.66   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 38   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.66   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0