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Tbio
NUSAP1
Nucleolar and spindle-associated protein 1

Protein Summary
Description
Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260359
  • ENSP00000260359
  • ENSG00000137804
  • ENST00000414849
  • ENSP00000400746
  • ENST00000450592
  • ENSP00000401014
  • ENST00000559596
  • ENSP00000453403
  • ENST00000560177
  • ENSP00000453657
  • ENST00000560747
  • ENSP00000454097

Symbol
  • ANKT
  • LNP
  • ANKT
  • SAPL
  • BM037
  • NUSAP
  • Q0310
  • PRO0310p1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
kinase perturbation
0.96
histone modification site profile
0.89
co-expressed gene
0.82
transcription factor binding site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.72   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.72   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (217)
C5orf30
Tdark
Novelty:  0.2072045
p_int:  0.999985526
p_ni:  0.000014468
p_wrong:  6e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
S100P
Tbio
Novelty:  0.03293676
p_int:  0.99116407
p_ni:  0.000370417
p_wrong:  0.008465512
Score:  0.519
Data Source:  BioPlex,STRINGDB
GAPDHS
Tbio
Family:  Enzyme
Novelty:  0.00885959
p_int:  0.964683005
p_ni:  0.035316972
p_wrong:  2.3e-8
Data Source:  BioPlex
GSTA2
Tbio
Family:  Enzyme
Novelty:  0.01131783
p_int:  0.961386568
p_ni:  0.034622113
p_wrong:  0.003991319
Score:  0.232
Data Source:  BioPlex,STRINGDB
B2M
Tbio
Novelty:  0.00011248
p_int:  0.944793119
p_ni:  0.055206881
Score:  0.524
Data Source:  BioPlex,STRINGDB
HP1BP3
Tbio
Novelty:  0.07014109
p_int:  0.93058778
p_ni:  0.06941222
Score:  0.315
Data Source:  BioPlex,STRINGDB
RANBP2
Tbio
Family:  Enzyme
Novelty:  0.00484823
p_int:  0.825481177
p_ni:  0.174518823
Score:  0.857
Data Source:  BioPlex,STRINGDB
RCC1
Tbio
Novelty:  0.00260884
p_int:  0.801537882
p_ni:  0.198462117
p_wrong:  1e-9
Score:  0.698
Data Source:  BioPlex,STRINGDB
CST6
Tbio
Novelty:  0.02811473
p_int:  0.78544256
p_ni:  0.213548366
p_wrong:  0.001009074
Data Source:  BioPlex
NUP153
Tbio
Novelty:  0.00696568
p_int:  0.783235129
p_ni:  0.216764871
Score:  0.221
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
70.1
1
1
0
1.1
43
lifestyle measurement
1
1
1
36.6
leukocyte count
1
1
1
36
eosinophil percentage of leukocytes
1
1
1
32.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
70.1
0
1.1
43
lifestyle measurement
1
36.6
leukocyte count
1
36
eosinophil percentage of leukocytes
1
32.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleolar and spindle associated protein 1
VGNC:1903
739741
Macaque
nucleolar and spindle associated protein 1
705972
Mouse
MGI:2675669
108907
Rat
RGD:1305764
311336
Dog
nucleolar and spindle associated protein 1
VGNC:44067
475154
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleolar and spindle associated protein 1
Macaque
nucleolar and spindle associated protein 1
Mouse
Rat
Dog
nucleolar and spindle associated protein 1
Publication Statistics
PubMed Score 92.72
PubMed score by year
PubTator Score 28.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title