Tbio NUP98 Nuclear pore complex protein Nup98-Nup96

Protein Summary

Description

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134). Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• P52948
• Q8IUT2
• Q8WYB0
• Q96E54
• Q9H3Q4
• Q9NT02
• Q9UF57
• Q9UHX0
• Q9Y6J4
• Q9Y6J5

Gene Name

• NUP98

Ensembl ID

• ENST00000324932
• ENSP00000316032
• ENSG00000110713
• ENST00000355260
• ENSP00000347404
• ENST00000359171
• ENSP00000352091
• ENST00000397004
• ENSP00000380199
• ENST00000397007
• ENSP00000380202

Symbol

• ADAR2
• ADIR2
• NUP96
• NUP196

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
pathway	1
virus perturbation	0.9
interacting protein	0.89
cellular component	0.81

Protein Classes

PANTHER Classes

Protein / Transporter / Nuclear Pore Complex Protein Nup98-nup96

Protein / ... / Serine Protease / Nuclear Pore Complex Protein Nup98-nup96

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Nuclear Pore Complex Protein Nup98-nup96

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.67   (req: < 5)

Gene RIFs: 113   (req: <= 3)

Antibodies: 295   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.67   (req: >= 5)

Gene RIFs: 113   (req: > 3)

Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0