Tbio NUP93 Nuclear pore complex protein Nup93

Protein Summary

Description

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• Q8N1F7
• B3KPQ8
• Q14705

Gene Name

• NUP93

Ensembl ID

• ENST00000308159
• ENSP00000310668
• ENSG00000102900
• ENST00000542526
• ENSP00000440235
• ENST00000564887
• ENSP00000458039

Symbol

• KIAA0095
• NIC96

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
drug perturbation	0.99
pathway	0.99
kinase perturbation	0.91
histone modification site profile	0.89

Protein Classes

PANTHER Classes

Protein / Transporter / Nuclear Pore Complex Protein Nup93

DTO Classes

Protein / Transporter / Nuclear Pore Complex Protein Nup93

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.35   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 111   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.35   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0