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Tbio
NUP62
Nuclear pore glycoprotein p62

Protein Summary
Description
Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352066
  • ENSP00000305503
  • ENSG00000213024
  • ENST00000422090
  • ENSP00000407331
  • ENST00000596217
  • ENSP00000471191
  • ENST00000597029
  • ENSP00000473192

Symbol
  • p62
  • IBSN
  • SNDI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.99
biological process
0.98
co-expressed gene
0.94
kinase perturbation
0.91


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.84   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.84   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (289)
TRAF3
Tbio
Novelty:  0.0022525
p_int:  0.999999886
p_ni:  1.13e-7
Score:  0.379
Data Source:  BioPlex,STRINGDB
RGPD8
Tdark
Novelty:  0.12397737
p_int:  0.999999839
p_ni:  1.61e-7
Score:  0.484
Data Source:  BioPlex,STRINGDB
CCHCR1
Tbio
Novelty:  0.03045656
p_int:  0.99999944
p_ni:  5.6e-7
Data Source:  BioPlex
NIN
Tbio
Novelty:  0.01312714
p_int:  0.999999331
p_ni:  6.69e-7
Data Source:  BioPlex
SDCCAG8
Tbio
Novelty:  0.0431837
p_int:  0.999993629
p_ni:  0.000006279
p_wrong:  9.3e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.999988868
p_ni:  0.000011132
Data Source:  BioPlex
RGPD5
Tdark
Novelty:  0.13776125
p_int:  0.999986577
p_ni:  0.000013423
Score:  0.484
Data Source:  BioPlex,STRINGDB
NUP54
Tbio
Novelty:  0.08155008
p_int:  0.999978191
p_ni:  0.00002181
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NEFM
Tbio
Novelty:  0.00239134
p_int:  0.999977453
p_ni:  0.000022547
Data Source:  BioPlex
PKN3
Tchem
Family:  Kinase
Novelty:  0.0516816
p_int:  0.999976108
p_ni:  0.000023892
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (72)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (54)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
1
2
35.5
aortic measurement
1
1
1
7.1
platelet count
1
1
1
2.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
35.5
aortic measurement
1
7.1
platelet count
1
2.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1351500
18226
Rat
RGD:619938
65274
Dog
nucleoporin 62
VGNC:44059
484370
Chicken
nucleoporin 62
CGNC:3605
422183
Zebrafish
ZDB-GENE-030131-8491
563392
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
nucleoporin 62
Chicken
nucleoporin 62
Zebrafish
Publication Statistics
PubMed Score 114.84
PubMed score by year
PubTator Score 902.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title