Tbio NUP50 Nuclear pore complex protein Nup50

Protein Summary

Description

Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UKX7
• B1AHA4
• B2RB15
• O75644
• Q8N6V5
• Q9NPM9
• Q9NPR6
• Q9P1K5

Gene Name

• NUP50

Ensembl ID

• ENST00000347635
• ENSP00000345895
• ENSG00000093000
• ENST00000396096
• ENSP00000379403
• ENST00000407019
• ENSP00000385555

Symbol

• NPAP60L
• NPAP60
• NPAP60L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.99
transcription factor perturbation	0.96
disease perturbation	0.95
virus perturbation	0.95
microRNA	0.94

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.13   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 336   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.13   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (230)

Explore Interacting Targets

1 – 10 of 230

• See Interactions on String-DB

KIFC1

Tchem

Novelty:  0.00982095

p_int:  0.999999982

p_ni:  1.4e-8

p_wrong:  4e-9

Score:  0.304

Data Source:  BioPlex,STRINGDB

RNGTT

Tbio

Novelty:  0.01433659

p_int:  0.999999686

p_ni:  3.14e-7

Score:  0.321

Data Source:  BioPlex,STRINGDB

WDHD1

Tbio

Novelty:  0.01511313

p_int:  0.999999385

p_ni:  6.15e-7

Score:  0.201

Data Source:  BioPlex,STRINGDB

BOD1L1

Tdark

Novelty:  0.26485597

p_int:  0.999997683

p_ni:  0.000002317

Score:  0.527

Data Source:  BioPlex,STRINGDB

KLHL7

Tbio

Novelty:  0.0522116

p_int:  0.999988226

p_ni:  0.000011774

Score:  0.173

Data Source:  BioPlex,STRINGDB

SPOP

Tbio

Novelty:  0.00663363

p_int:  0.999935655

p_ni:  0.000064341

p_wrong:  4e-9

Score:  0.186

Data Source:  BioPlex,STRINGDB

ARID2

Tbio

Family:  TF

Novelty:  0.01767212

p_int:  0.999930425

p_ni:  0.000069574

p_wrong:  1e-9

Score:  0.539

Data Source:  BioPlex,STRINGDB

PBRM1

Tchem

Family:  TF; Epigenetic

Novelty:  0.00608093

p_int:  0.999910299

p_ni:  0.000089701

Score:  0.632

Data Source:  BioPlex,STRINGDB

CXXC1

Tbio

Family:  Epigenetic

Novelty:  0.01019251

p_int:  0.999794293

p_ni:  0.000205707

Score:  0.199

Data Source:  BioPlex,STRINGDB

PHF10

Tbio

Family:  Epigenetic

Novelty:  0.05941323

p_int:  0.999745475

p_ni:  0.000254525

Score:  0.528

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (69)

Reactome (68)

KEGG (1)

Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Cellular response to heat stress	100 targets	R-HSA-3371556
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Name	Explore in Pharos	Explore in Source
Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Cellular response to heat stress	100 targets	R-HSA-3371556
Cellular responses to external stimuli	487 targets	R-HSA-8953897

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (1)

Components (7)

Processes (4)

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1 – 1 of 1

GO Term	Evidence	Assigned by
Ran GTPase binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
basophil percentage of leukocytes	EFO_0007992	1	1	1		72.9
basophil count	EFO_0005090	2	2	2		70.9
suntan	EFO_0004279	1	1	1		59
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		55.2
cutaneous melanoma	EFO_0000389	1	1	0	1.1	35

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Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
basophil percentage of leukocytes	EFO_0007992	1		72.9
basophil count	EFO_0005090	2		70.9
suntan	EFO_0004279	1		59
mean corpuscular hemoglobin concentration	EFO_0004528	1		55.2
cutaneous melanoma	EFO_0000389	0	1.1	35

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Isopeptide bond
Membrane
mRNA transport
Nuclear pore complex
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
basophil count
basophil percentage of leukocytes
cutaneous melanoma
hair color
mean corpuscular hemoglobin concentration
suntan

MGI Phenotype Find Similar Targets

No Header	No Header
embryo phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	nucleoporin 50		713282
Mouse	nucleoporin 50	MGI:1351502	18141
Rat	nucleoporin 50	RGD:3191	25497
Dog	nucleoporin 50	VGNC:44056	474470
Horse	nucleoporin 50	VGNC:20971	100051494

Species	Name	OMA	EggNOG	Inparanoid
Macaque	nucleoporin 50
Mouse	nucleoporin 50
Rat	nucleoporin 50
Dog	nucleoporin 50
Horse	nucleoporin 50

Publication Statistics

PubMed Score 28.13

PubMed score by year

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PubTator Score 13.15

PubTator score by year

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Related Publications

Text Mined References (24)

GeneRif Annotations (6)

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10

0 of 0

PMID	Year	Title