Protein Summary
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008]
- ENST00000340413
- ENSP00000342262
- ENSG00000120253
- ENST00000367404
- ENSP00000356374
- p42
- bA350J20.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
pathway | 1 | ||
transcription factor perturbation | 0.74 | ||
cellular component | 0.7 | ||
biological process | 0.67 | ||
transcription factor binding site profile | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.01 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 195 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.01 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 195 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (264)
TPRKB
Novelty: 0.1035085
p_int: 0.999917847
p_ni: 0.000082153
Score: 0.757
Data Source: BioPlex,STRINGDB
NUP98
Family: Enzyme
Novelty: 0.00401452
p_int: 0.999913269
p_ni: 0.000086731
Score: 0.999
Data Source: BioPlex,STRINGDB
KLC4
Novelty: 0.32552746
p_int: 0.9998631
p_ni: 0.000136899
Score: 0.158
Data Source: BioPlex,STRINGDB
NUP85
Novelty: 0.02350514
p_int: 0.999794211
p_ni: 0.000205789
Score: 0.999
Data Source: BioPlex,STRINGDB
OSGEP
Family: Enzyme
Novelty: 0.0106198
p_int: 0.999615467
p_ni: 0.000384533
Score: 0.756
Data Source: BioPlex,STRINGDB
NUP107
Novelty: 0.01994155
p_int: 0.999534073
p_ni: 0.000465927
Score: 0.999
Data Source: BioPlex,STRINGDB
TP53RK
Family: Kinase
Novelty: 0.04302252
p_int: 0.998737133
p_ni: 0.001262867
Score: 0.763
Data Source: BioPlex,STRINGDB
NUP160
Novelty: 0.03667026
p_int: 0.998616281
p_ni: 0.001383359
p_wrong: 3.6e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
NUP37
Novelty: 0.1270421
p_int: 0.998548823
p_ni: 0.001451177
Score: 0.999
Data Source: BioPlex,STRINGDB
XPA
Novelty: 0.00137698
p_int: 0.998303008
p_ni: 0.001696992
Score: 0.188
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (82)
Reactome (81)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Reactome | Amplification of signal from the kinetochores | ||||
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Amplification of signal from the kinetochores | ||||
Antiviral mechanism by IFN-stimulated genes | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Components (4)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 1.1 | 7.3 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 7.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | nucleoporin 43 | VGNC:3601 | 472151 | |||||
Mouse | MGI:1917162 | 69912 | ||||||
Rat | RGD:1596513 | 683983 | ||||||
Dog | nucleoporin 43 | VGNC:44055 | 484031 | |||||
Horse | nucleoporin 43 | VGNC:20970 | 100064615 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | nucleoporin 43 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nucleoporin 43 | |||||
Horse | nucleoporin 43 | |||||
Publication Statistics
PubMed Score 9.01
PubMed score by year
PubTator Score 2.05
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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