Tbio NUP43 Nucleoporin Nup43

Protein Summary

Description

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8NFH3
• B4E2F0
• Q9H8S0

Gene Name

• NUP43

Ensembl ID

• ENST00000340413
• ENSP00000342262
• ENSG00000120253
• ENST00000367404
• ENSP00000356374

Symbol

• p42
• bA350J20.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	1
transcription factor perturbation	0.74
cellular component	0.7
biological process	0.67
transcription factor binding site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.01   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 195   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.01   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (264)

Explore Interacting Targets

1 – 10 of 264

• See Interactions on String-DB

TPRKB

Tbio

Novelty:  0.1035085

p_int:  0.999917847

p_ni:  0.000082153

Score:  0.757

Data Source:  BioPlex,STRINGDB

NUP98

Tbio

Family:  Enzyme

Novelty:  0.00401452

p_int:  0.999913269

p_ni:  0.000086731

Score:  0.999

Data Source:  BioPlex,STRINGDB

KLC4

Tdark

Novelty:  0.32552746

p_int:  0.9998631

p_ni:  0.000136899

Score:  0.158

Data Source:  BioPlex,STRINGDB

NUP85

Tbio

Novelty:  0.02350514

p_int:  0.999794211

p_ni:  0.000205789

Score:  0.999

Data Source:  BioPlex,STRINGDB

OSGEP

Tbio

Family:  Enzyme

Novelty:  0.0106198

p_int:  0.999615467

p_ni:  0.000384533

Score:  0.756

Data Source:  BioPlex,STRINGDB

NUP107

Tbio

Novelty:  0.01994155

p_int:  0.999534073

p_ni:  0.000465927

Score:  0.999

Data Source:  BioPlex,STRINGDB

TP53RK

Tbio

Family:  Kinase

Novelty:  0.04302252

p_int:  0.998737133

p_ni:  0.001262867

Score:  0.763

Data Source:  BioPlex,STRINGDB

NUP160

Tbio

Novelty:  0.03667026

p_int:  0.998616281

p_ni:  0.001383359

p_wrong:  3.6e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

NUP37

Tbio

Novelty:  0.1270421

p_int:  0.998548823

p_ni:  0.001451177

Score:  0.999

Data Source:  BioPlex,STRINGDB

XPA

Tchem

Novelty:  0.00137698

p_int:  0.998303008

p_ni:  0.001696992

Score:  0.188

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (82)

Reactome (81)

KEGG (1)

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Reactome	Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Reactome	Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620

Name	Explore in Pharos	Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Components (4)

Processes (5)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
nuclear pore outer ring	Inferred from Direct Assay (IDA)	UniProtKB
cytosol	Traceable Author Statement (TAS)	Reactome
nuclear envelope	Traceable Author Statement (TAS)	Reactome
condensed chromosome kinetochore	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations ()

No disease associations found

GWAS Traits (1)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Testicular Germ Cell Tumor	EFO_1000566	1	1	0	1.1	7.3

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Testicular Germ Cell Tumor	EFO_1000566	0	1.1	7.3

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Cell cycle
Cell division
Centromere
Chromosome
Chromosome partition
Complete proteome
Kinetochore

GWAS Trait Find Similar Targets

No Header	No Header
Testicular Germ Cell Tumor

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nucleoporin 43	VGNC:3601	472151
Mouse	nucleoporin 43	MGI:1917162	69912
Rat	nucleoporin 43	RGD:1596513	683983
Dog	nucleoporin 43	VGNC:44055	484031
Horse	nucleoporin 43	VGNC:20970	100064615

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nucleoporin 43
Mouse	nucleoporin 43
Rat	nucleoporin 43
Dog	nucleoporin 43
Horse	nucleoporin 43

Publication Statistics

PubMed Score 9.01

PubMed score by year

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PubTator Score 2.05

PubTator score by year

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Related Publications

Text Mined References (16)

GeneRif Annotations (2)

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10

0 of 0

PMID	Year	Title