Protein Summary
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC. This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013]
- ENST00000295119
- ENSP00000295119
- ENSG00000163002
- ENST00000409798
- ENSP00000387305
- MP44
- NUP53
- MP44
- NP44
- MP-44
- NUP53
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.99 | ||
transcription factor binding site profile | 0.86 | ||
histone modification site profile | 0.84 | ||
kinase perturbation | 0.84 | ||
cellular component | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.74 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 201 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.74 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 201 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (203)
AAAS
Novelty: 0.00830233
p_int: 0.999953001
p_ni: 0.000046999
Score: 0.955
Data Source: BioPlex,STRINGDB
KCTD9
Novelty: 0.22841768
p_int: 0.998787041
p_ni: 0.001212944
p_wrong: 1.5e-8
Score: 0.261
Data Source: BioPlex,STRINGDB
FAM136A
Novelty: 0.4050275
p_int: 0.996918358
p_ni: 0.003081636
p_wrong: 6e-9
Score: 0.194
Data Source: BioPlex,STRINGDB
ATP23
Family: Enzyme
Novelty: 0.09823059
p_int: 0.99538049
p_ni: 0.004609766
p_wrong: 0.000009745
Score: 0.665
Data Source: BioPlex,STRINGDB
CCL3L1
Novelty: 0.01124082
p_int: 0.993008458
p_ni: 0.006991535
p_wrong: 8e-9
Data Source: BioPlex
C16orf70
Novelty: 2.12573065
p_int: 0.975315367
p_ni: 0.024684633
p_wrong: 1e-9
Data Source: BioPlex
WDYHV1
Family: Enzyme
Novelty: 0.1844203
p_int: 0.952449997
p_ni: 0.047550002
Data Source: BioPlex
TRPV5
Family: IC
Novelty: 0.0055156
p_int: 0.923107725
p_ni: 0.076892218
p_wrong: 5.7e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (69)
Reactome (68)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Antiviral mechanism by IFN-stimulated genes | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (7)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | nucleoporin 35 | VGNC:2736 | 459802 | |||||
Macaque | nucleoporin 35 | 706497 | ||||||
Mouse | MGI:1916732 | 69482 | ||||||
Mouse | MGI:3782538 | 100043313 | ||||||
Rat | RGD:1303069 | 295692 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | nucleoporin 35 | |||||
Macaque | nucleoporin 35 | |||||
Mouse | ||||||
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 27.74
PubMed score by year
PubTator Score 10.95
PubTator score by year
Related Publications
Text Mined References (20)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
|---|