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Tbio
NUP153
Nuclear pore complex protein Nup153

Protein Summary
Description
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262077
  • ENSP00000262077
  • ENSG00000124789
  • ENST00000537253
  • ENSP00000444029
  • ENST00000613258
  • ENSP00000478627

Symbol
  • N153
  • HNUP153
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.99
transcription factor binding site profile
0.98
drug perturbation
0.96
biological process
0.85
cellular component
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.85   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.85   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (263)
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.999734833
p_ni:  0.000265167
Score:  0.999
Data Source:  BioPlex,STRINGDB
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
p_int:  0.998703133
p_ni:  0.001296867
Score:  0.995
Data Source:  BioPlex,STRINGDB
KPNA2
Tbio
Novelty:  0.00506958
p_int:  0.998310668
p_ni:  0.001689332
Score:  0.994
Data Source:  BioPlex,STRINGDB
NXF2
Tbio
Novelty:  0.04733504
p_int:  0.923089965
p_ni:  0.076910035
Score:  0.859
Data Source:  BioPlex,STRINGDB
SREK1IP1
Tdark
Novelty:  1.39429464
p_int:  0.896144971
p_ni:  0.103855029
p_wrong:  1e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.89027547
p_ni:  0.10972453
Score:  0.17
Data Source:  BioPlex,STRINGDB
TSR1
Tbio
Novelty:  0.01639069
p_int:  0.880250668
p_ni:  0.119749332
Score:  0.307
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.864581109
p_ni:  0.135418891
Score:  0.23
Data Source:  BioPlex,STRINGDB
G3BP2
Tbio
Family:  Enzyme
Novelty:  0.04786241
p_int:  0.838680456
p_ni:  0.161319544
Score:  0.382
Data Source:  BioPlex,STRINGDB
NUSAP1
Tbio
Novelty:  0.01702118
p_int:  0.783235129
p_ni:  0.216764871
Score:  0.221
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (75)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 153
VGNC:3600
462455
Macaque
nucleoporin 153
703888
Mouse
MGI:2385621
218210
Rat
RGD:3216
25281
Dog
nucleoporin 153
478732
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 153
Macaque
nucleoporin 153
Mouse
Rat
Dog
nucleoporin 153
Publication Statistics
PubMed Score 143.85
PubMed score by year
PubTator Score 84.79
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title