Tbio NUP107 Nuclear pore complex protein Nup107

Protein Summary

Description

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P57740
• B4DZ67
• Q6PJE1

Gene Name

• NUP107

Ensembl ID

• ENST00000229179
• ENSP00000229179
• ENSG00000111581
• ENST00000378905
• ENSP00000368185
• ENST00000539906
• ENSP00000441448

Symbol

• ODG6
• NUP84
• NPHS11
• ODG6; GAMOS7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
histone modification site profile	0.92
interacting protein	0.86
transcription factor binding site profile	0.85
virus perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Transporter / Nuclear Pore Complex Protein Nup107

DTO Classes

Protein / Transporter / Nuclear Pore Complex Protein Nup107

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.2   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 219   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.2   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (322)

Explore Interacting Targets

1 – 10 of 322

• See Interactions on String-DB

NUP133

Tbio

Novelty:  0.02115225

p_int:  0.999915315

p_ni:  0.000084685

Score:  0.999

Data Source:  BioPlex,STRINGDB

NUP43

Tbio

Novelty:  0.11571309

p_int:  0.999534073

p_ni:  0.000465927

Score:  0.999

Data Source:  BioPlex,STRINGDB

SEC13

Tbio

Novelty:  0.00709413

p_int:  0.994727548

p_ni:  0.005272452

Score:  0.999

Data Source:  BioPlex,STRINGDB

SPAST

Tbio

Novelty:  0.00303236

p_int:  0.986719872

p_ni:  0.013280128

Score:  0.705

Data Source:  BioPlex,STRINGDB

UXS1

Tbio

Family:  Enzyme

Novelty:  0.04671281

p_int:  0.835211247

p_ni:  0.164788753

Data Source:  BioPlex

SIGLECL1

Tdark

p_int:  0.790388368

p_ni:  0.209611632

Data Source:  BioPlex

CD70

Tbio

Novelty:  0.00420393

p_int:  0.75971839

p_ni:  0.24028161

Data Source:  BioPlex

SEH1L

Tbio

Novelty:  0.03666501

Score:  0.999

Data Source:  STRINGDB

NUP98

Tbio

Family:  Enzyme

Novelty:  0.00401452

Score:  0.999

Data Source:  STRINGDB

NUP160

Tbio

Novelty:  0.03667026

Score:  0.999

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (83)

Reactome (81)

KEGG (1)

WikiPathways (1)

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Reactome	Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Reactome	Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620

Name	Explore in Pharos	Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (1)

Components (8)

Processes (6)

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1 – 1 of 1

GO Term	Evidence	Assigned by
structural constituent of nuclear pore	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (4)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		44.2
mean reticulocyte volume	EFO_0010701	1	1	1		29
red blood cell density measurement	EFO_0007978	1	1	1		21.4
mean corpuscular volume	EFO_0004526	1	1	1		7.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	1		44.2
mean reticulocyte volume	EFO_0010701	1		29
red blood cell density measurement	EFO_0007978	1		21.4
mean corpuscular volume	EFO_0004526	1		7.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Centromere
Chromosome
Complete proteome
Disease mutation
Kinetochore
Membrane
Methylation

GWAS Trait Find Similar Targets

No Header	No Header
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean reticulocyte volume
red blood cell density measurement

MGI Phenotype Find Similar Targets

No Header	No Header
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nucleoporin 107	VGNC:5513	467062
Macaque	nucleoporin 107		718214
Mouse	nucleoporin 107	MGI:2143854	103468
Rat	nucleoporin 107	RGD:621160	116555
Dog	nucleoporin 107	VGNC:44044	474440

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nucleoporin 107
Macaque	nucleoporin 107
Mouse	nucleoporin 107
Rat	nucleoporin 107
Dog	nucleoporin 107

Publication Statistics

PubMed Score 54.20

PubMed score by year

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PubTator Score 38.53

PubTator score by year

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Related Publications

Text Mined References (46)

GeneRif Annotations (23)

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PMID	Year	Title