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Tbio
NUF2
Kinetochore protein Nuf2

Protein Summary
Description
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mito ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271452
  • ENSP00000271452
  • ENSG00000143228
  • ENST00000367900
  • ENSP00000356875

Symbol
  • CDCA1
  • NUF2R
  • CDCA1
  • CT106
  • NUF2R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
histone modification site profile
0.9
interacting protein
0.89
drug perturbation
0.71
cellular component
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.61   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.61   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (295)
SPC24
Tbio
Novelty:  0.03166479
p_int:  0.999999767
p_ni:  2.33e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SPC25
Tbio
Novelty:  0.26354244
p_int:  0.999998771
p_ni:  0.000001229
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DSN1
Tbio
Novelty:  0.05336903
p_int:  0.999985187
p_ni:  0.000014813
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
NSL1
Tbio
Novelty:  0.01396984
p_int:  0.999962695
p_ni:  0.000037305
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
PMF1
Tbio
Novelty:  0.05319446
p_int:  0.999681429
p_ni:  0.00031857
p_wrong:  1e-9
Score:  0.371
Data Source:  BioPlex,Reactome,STRINGDB
TPST2
Tbio
Family:  Enzyme
Novelty:  0.02551048
p_int:  0.99937094
p_ni:  0.00062906
Data Source:  BioPlex
ZWINT
Tbio
Novelty:  0.02153276
p_int:  0.997870174
p_ni:  0.002129826
Score:  0.998
Data Source:  BioPlex,STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.988308392
p_ni:  0.011691485
p_wrong:  1.23e-7
Data Source:  BioPlex
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.987887851
p_ni:  0.012112148
Data Source:  BioPlex
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.960530971
p_ni:  0.039469015
p_wrong:  1.4e-8
Score:  0.931
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
61.8
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NUF2, NDC80 kinetochore complex component
VGNC:8441
457472
Macaque
NUF2, NDC80 kinetochore complex component
693637
Mouse
MGI:1914227
66977
Rat
RGD:1307952
304951
Dog
NUF2, NDC80 kinetochore complex component
VGNC:44038
478988
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NUF2, NDC80 kinetochore complex component
Macaque
NUF2, NDC80 kinetochore complex component
Mouse
Rat
Dog
NUF2, NDC80 kinetochore complex component
Publication Statistics
PubMed Score 109.61
PubMed score by year
PubTator Score 36.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title