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Tdark
NUDT8
Nucleoside diphosphate-linked moiety X motif 8

Protein Summary
Description
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301490
  • ENSP00000301490
  • ENSG00000167799
  • ENST00000376693
  • ENSP00000365883
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
cell type or tissue
0.62
tissue sample
0.62
transcription factor binding site profile
0.62
cell line
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.67   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.67   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
ODAPH
Tbio
Novelty:  0.20386223
p_int:  0.999998484
p_ni:  0.000001515
p_wrong:  1e-9
Score:  0.311
Data Source:  BioPlex,STRINGDB
PMPCA
Tbio
Family:  Enzyme
Novelty:  0.01842996
p_int:  0.999980787
p_ni:  0.000004316
p_wrong:  0.000014897
Score:  0.91
Data Source:  BioPlex,STRINGDB
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.999898264
p_ni:  0.000101672
p_wrong:  6.4e-8
Score:  0.518
Data Source:  BioPlex,STRINGDB
SPINK2
Tdark
Family:  Enzyme
Novelty:  0.06832697
p_int:  0.999709487
p_ni:  0.000289695
p_wrong:  8.18e-7
Score:  0.656
Data Source:  BioPlex,STRINGDB
CCDC69
Tdark
Novelty:  0.37983713
p_int:  0.998551712
p_ni:  0.001263031
p_wrong:  0.000185257
Score:  0.554
Data Source:  BioPlex,STRINGDB
CDRT15
Tdark
Novelty:  1.16705127
p_int:  0.995704003
p_ni:  0.004295991
p_wrong:  6e-9
Score:  0.513
Data Source:  BioPlex,STRINGDB
FAM174B
Tdark
Novelty:  0.54823112
Score:  0.762
Data Source:  STRINGDB
UQCRC1
Tbio
Family:  Enzyme
Novelty:  0.01746759
Score:  0.739
Data Source:  STRINGDB
PMPCB
Tbio
Family:  Enzyme
Novelty:  0.0244013
Score:  0.732
Data Source:  STRINGDB
QARS
Tchem
Family:  Enzyme
Novelty:  0.01684657
Score:  0.723
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
3
5
7
84.2
BMI-adjusted hip circumference
2
4
4
76
urinary metabolite measurement
1
1
1
65.3
serum metabolite measurement
1
1
1
43.8
BMI-adjusted waist-hip ratio
2
2
2
41.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
7
84.2
BMI-adjusted hip circumference
4
76
urinary metabolite measurement
1
65.3
serum metabolite measurement
1
43.8
BMI-adjusted waist-hip ratio
2
41.1
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 8
VGNC:3083
466894
Mouse
MGI:1913637
66387
Rat
RGD:1309040
361692
Dog
nudix hydrolase 8
VGNC:44036
610433
Horse
nudix hydrolase 8
VGNC:20952
100146252
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 8
Mouse
Rat
Dog
nudix hydrolase 8
Horse
nudix hydrolase 8
Publication Statistics
PubMed Score 1.67
PubMed score by year
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Related Publications
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PMID
Year
Title