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Tbio
NUDT6
Nucleoside diphosphate-linked moiety X motif 6

Protein Summary
Description
May contribute to the regulation of cell proliferation. This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304430
  • ENSP00000306070
  • ENSG00000170917
  • ENST00000339154
  • ENSP00000344011
  • ENST00000502270
  • ENSP00000424117

Symbol
  • FGF2AS
  • GFG1
  • GFG-1
  • ASFGF2
  • FGF-AS
  • FGF2AS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor perturbation
0.84
tissue sample
0.67
gene perturbation
0.58
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.51   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.51   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
MRPS18C
Tdark
Novelty:  0.42868428
p_int:  0.9999865
p_ni:  0.000006123
p_wrong:  0.000007378
Data Source:  BioPlex
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.999983265
p_ni:  0.000016735
Data Source:  BioPlex
TINAG
Tbio
Novelty:  0.04582927
p_int:  0.999833612
p_ni:  0.000166343
p_wrong:  4.5e-8
Score:  0.175
Data Source:  BioPlex,STRINGDB
ISCA1
Tbio
Novelty:  0.01288069
p_int:  0.999720862
p_ni:  0.000277873
p_wrong:  0.000001266
Data Source:  BioPlex
NRGN
Tbio
Novelty:  0.00352757
p_int:  0.998822309
p_ni:  0.001139677
p_wrong:  0.000038014
Score:  0.239
Data Source:  BioPlex,STRINGDB
BOLA3
Tbio
Novelty:  0.06292339
p_int:  0.998128289
p_ni:  0.000228031
p_wrong:  0.001643679
Score:  0.28
Data Source:  BioPlex,STRINGDB
UBLCP1
Tchem
Family:  Enzyme
Novelty:  0.14438023
p_int:  0.996663745
p_ni:  0.003292499
p_wrong:  0.000043756
Score:  0.28
Data Source:  BioPlex,STRINGDB
DENR
Tbio
Novelty:  0.00653432
p_int:  0.95407376
p_ni:  0.045898463
p_wrong:  0.000027776
Data Source:  BioPlex
MMAB
Tbio
Family:  Enzyme
Novelty:  0.01681296
p_int:  0.873129552
p_ni:  0.12681028
p_wrong:  0.000060168
Score:  0.189
Data Source:  BioPlex,STRINGDB
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.75222629
p_ni:  0.247773707
p_wrong:  3e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
1
1
1
29
1
1
1
21.5
waist-hip ratio
1
1
1
15.8
BMI-adjusted waist-hip ratio
1
1
1
14.2
mosquito bite reaction itch intensity measurement
1
1
1
11.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
1
29
1
21.5
waist-hip ratio
1
15.8
BMI-adjusted waist-hip ratio
1
14.2
mosquito bite reaction itch intensity measurement
1
11.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 6
VGNC:2969
461473
Mouse
MGI:2387618
229228
Rat
RGD:621356
207120
Dog
nudix hydrolase 6
VGNC:54811
483841
Horse
nudix hydrolase 6
VGNC:20950
100072122
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 6
Mouse
Rat
Dog
nudix hydrolase 6
Horse
nudix hydrolase 6
Publication Statistics
PubMed Score 25.51
PubMed score by year
PubTator Score 10.06
PubTator score by year
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Related Publications
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PMID
Year
Title