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Tbio
NUDT5
ADP-sugar pyrophosphatase

Protein Summary
Description
Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:19699693, PubMed:21389046, PubMed:17052728). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). This gene belongs to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000491614
  • ENSP00000419628
  • ENSG00000165609
  • ENST00000537776
  • ENSP00000445116

Symbol
  • NUDIX5
  • YSA1
  • YSA1H
  • YSAH1
  • hNUDT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
transcription factor binding site profile
0.9
drug perturbation
0.87
histone modification site profile
0.86
small molecule perturbation
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
RFLNB
Tbio
Novelty:  0.09562879
p_int:  0.999999995
p_wrong:  5e-9
Data Source:  BioPlex
PYCR2
Tbio
Family:  Enzyme
Novelty:  0.05660996
p_int:  0.999767818
p_ni:  0.000232182
Score:  0.873
Data Source:  BioPlex,STRINGDB
PYCR1
Tbio
Family:  Enzyme
Novelty:  0.00220832
p_int:  0.999714432
p_ni:  0.000285568
Score:  0.94
Data Source:  BioPlex,STRINGDB
FLNC
Tbio
Novelty:  0.00463205
p_int:  0.99970651
p_ni:  0.00029349
Data Source:  BioPlex
FLNB
Tbio
Novelty:  0.00568768
p_int:  0.999513872
p_ni:  0.000486129
Score:  0.272
Data Source:  BioPlex,STRINGDB
FLNA
Tbio
Novelty:  0.00156479
p_int:  0.999424629
p_ni:  0.000575372
Data Source:  BioPlex
PPAT
Tclin
Family:  Enzyme
Novelty:  0.01549862
p_int:  0.929562764
p_ni:  0.070437236
Score:  0.555
Data Source:  BioPlex,STRINGDB
NUDT9
Tbio
Family:  Enzyme
Novelty:  0.0482661
Score:  0.938
Data Source:  STRINGDB
PRPS1
Tbio
Family:  Kinase
Novelty:  0.01139656
Score:  0.934
Data Source:  STRINGDB
PRPS2
Tbio
Family:  Kinase
Novelty:  0.02472415
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Phosphate bond hydrolysis by NUDT proteins
Reactome
Purine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Phosphate bond hydrolysis by NUDT proteins
Purine catabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
15
7
4
1.1
98.2
forced expiratory volume
4
3
3
1.2
93.3
FEV/FEC ratio
1
1
1
86
peak expiratory flow
1
1
1
81.5
HbA1c measurement
3
2
3
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
98.2
forced expiratory volume
3
1.2
93.3
FEV/FEC ratio
1
86
peak expiratory flow
1
81.5
HbA1c measurement
3
78.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 5
VGNC:12411
450306
Macaque
nudix hydrolase 5
694368
Mouse
MGI:1858232
53893
Rat
RGD:1359284
361274
Dog
nudix hydrolase 5
VGNC:44034
478006
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 5
Macaque
nudix hydrolase 5
Mouse
Rat
Dog
nudix hydrolase 5
Publication Statistics
PubMed Score 44.00
PubMed score by year
PubTator Score 19.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title