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Tbio
NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

Protein Summary
Description
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000607016
  • ENSP00000476119
  • ENSG00000272325

Symbol
  • DIPP
  • DIPP1
  • DIPP
  • DIPP1
  • DIPP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.99
co-expressed gene
0.97
kinase perturbation
0.91
transcription factor binding site profile
0.9


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.8   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.8   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (161)
NUDT10
Tbio
Family:  Enzyme
Novelty:  0.01340726
p_int:  0.999999796
p_ni:  1.65e-7
p_wrong:  3.9e-8
Data Source:  BioPlex
HSPA1A
Tchem
Novelty:  0.00069195
p_int:  0.999993174
p_ni:  0.000006826
Data Source:  BioPlex
RHBDF2
Tbio
Family:  Enzyme
Novelty:  0.02487334
Score:  0.905
Data Source:  STRINGDB
RPS29
Tbio
Novelty:  0.02619305
Score:  0.748
Data Source:  STRINGDB
ETF1
Tbio
Family:  Enzyme
Novelty:  0.00711627
Score:  0.742
Data Source:  STRINGDB
P35544
Tbio
Novelty:  0.01170009
Score:  0.738
Data Source:  STRINGDB
P62861
Tbio
Novelty:  0.01170009
Score:  0.738
Data Source:  STRINGDB
RPS13
Tbio
Novelty:  0.0019983
Score:  0.716
Data Source:  STRINGDB
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
Score:  0.715
Data Source:  STRINGDB
RPL31
Tbio
Novelty:  0.03427872
Score:  0.714
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of pyrophosphates in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of pyrophosphates in the cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (48)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
15
72
82
8.8
99.7
BMI-adjusted waist circumference
7
19
33
99.3
BMI-adjusted waist-hip ratio
6
16
18
99.3
waist-hip ratio
4
13
16
99.1
waist circumference
2
10
10
98.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
82
8.8
99.7
BMI-adjusted waist circumference
33
99.3
BMI-adjusted waist-hip ratio
18
99.3
waist-hip ratio
16
99.1
waist circumference
10
98.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nudix hydrolase 3
718568
Mouse
MGI:1928484
56409
Rat
RGD:1310183
294292
Dog
nudix (nucleoside diphosphate linked moiety X)-type motif 3
100846983
Horse
nudix hydrolase 3
VGNC:52416
102149351
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nudix hydrolase 3
Mouse
Rat
Dog
nudix (nucleoside diphosphate linked moiety X)-type motif 3
Horse
nudix hydrolase 3
Publication Statistics
PubMed Score 16.80
PubMed score by year
PubTator Score 30.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title