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Tbio
NUDT2
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Protein Summary
Description
Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346365
  • ENSP00000344187
  • ENSG00000164978
  • ENST00000379155
  • ENSP00000368452
  • ENST00000379158
  • ENSP00000368455
  • ENST00000618590
  • ENSP00000482384

Symbol
  • APAH1
  • APAH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
histone modification site profile
0.86
kinase perturbation
0.71
tissue sample
0.65
cell type or tissue
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.08   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.08   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (155)
ANKRD22
Tbio
Novelty:  0.28856283
p_int:  0.962055064
p_ni:  0.036553653
p_wrong:  0.001391283
Data Source:  BioPlex
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.923
Data Source:  STRINGDB
ENTPD3
Tbio
Family:  Enzyme
Novelty:  0.01673548
Score:  0.917
Data Source:  STRINGDB
CTPS1
Tbio
Family:  Enzyme
Novelty:  0.00911596
Score:  0.911
Data Source:  STRINGDB
CTPS2
Tbio
Family:  Enzyme
Novelty:  0.06147923
Score:  0.909
Data Source:  STRINGDB
NME2
Tbio
Family:  Kinase
Novelty:  0.00257937
Score:  0.906
Data Source:  STRINGDB
AK9
Tbio
Family:  Kinase
Novelty:  0.06306357
Score:  0.906
Data Source:  STRINGDB
NME3
Tbio
Family:  Kinase
Novelty:  0.05947052
Score:  0.905
Data Source:  STRINGDB
PKM
Tchem
Family:  Kinase
Novelty:  0.00076567
Score:  0.905
Data Source:  STRINGDB
NME6
Tbio
Family:  Kinase
Novelty:  0.12087274
Score:  0.905
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 5 of 5
GUCY1B1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
NPR1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
GUCY1A2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
GUCY1A1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
GUCY2C
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
Pathways (7)
Cellular responses to external stimuli (R-HSA-8953897)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
1
1
0
1.7
33.1
creatine kinase measurement
1
1
1
17.8
self reported educational attainment
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
0
1.7
33.1
creatine kinase measurement
1
17.8
self reported educational attainment
1
15.8
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 48.08
PubMed score by year
PubTator Score 12.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title