You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NUDT16L1
Tudor-interacting repair regulator protein

Protein Summary
Description
Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304301
  • ENSP00000306670
  • ENSG00000168101
  • ENST00000405142
  • ENSP00000458144

Symbol
  • SDOS
  • TIRR
  • SDOS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor perturbation
0.84
histone modification site profile
0.82
kinase perturbation
0.71
interacting protein
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.25   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.25   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
NUDT16
Tbio
Novelty:  0.06032864
p_int:  0.999999576
p_ni:  1e-9
p_wrong:  4.24e-7
Score:  0.565
Data Source:  BioPlex,STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
p_int:  0.995455047
p_ni:  0.004544953
Score:  0.896
Data Source:  BioPlex,STRINGDB
CRYAB
Tchem
Novelty:  0.00464213
p_int:  0.980224458
p_ni:  0.019775542
Score:  0.205
Data Source:  BioPlex,STRINGDB
VEGFB
Tclin
Novelty:  0.00293322
p_int:  0.750814652
p_ni:  0.249185348
Score:  0.282
Data Source:  BioPlex,STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.946
Data Source:  STRINGDB
STK40
Tbio
Family:  Kinase
Novelty:  0.10461675
Score:  0.698
Data Source:  STRINGDB
PXN
Tbio
Novelty:  0.00082031
Score:  0.632
Data Source:  STRINGDB
ERH
Tbio
Novelty:  0.00711649
Score:  0.624
Data Source:  STRINGDB
OR6P1
Tdark
Family:  oGPCR
Novelty:  11.7597471
Score:  0.559
Data Source:  STRINGDB
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
Score:  0.538
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
85.6
hemoglobin measurement
2
1
2
51.4
high density lipoprotein cholesterol measurement
3
2
3
47.5
hematocrit
1
1
1
46.9
testosterone measurement
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
85.6
hemoglobin measurement
2
51.4
high density lipoprotein cholesterol measurement
3
47.5
hematocrit
1
46.9
testosterone measurement
1
46.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 16 like 1
VGNC:5856
453885
Macaque
nudix hydrolase 16 like 1
706072
Mouse
MGI:1914161
66911
Rat
RGD:1561451
497867
Dog
nudix hydrolase 16 like 1
VGNC:44029
479862
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 16 like 1
Macaque
nudix hydrolase 16 like 1
Mouse
Rat
Dog
nudix hydrolase 16 like 1
Publication Statistics
PubMed Score 19.25
PubMed score by year
PubTator Score 8.25
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title