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Tbio
NUDT14
Uridine diphosphate glucose pyrophosphatase

Protein Summary
Description
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose. The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392568
  • ENSP00000376349
  • ENSG00000183828

Symbol
  • UGPP
  • UGPP
  • UGPPase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
virus perturbation
0.79
histone modification site profile
0.73
transcription factor
0.6
tissue sample
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.51   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.51   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
AHNAK2
Tbio
Novelty:  0.05663435
p_int:  0.999619773
p_ni:  0.000375645
p_wrong:  0.000004582
Score:  0.243
Data Source:  BioPlex,STRINGDB
UGP2
Tbio
Family:  Enzyme
Novelty:  0.00760963
Score:  0.907
Data Source:  STRINGDB
NUDT18
Tbio
Family:  Enzyme
Novelty:  0.24672611
Score:  0.634
Data Source:  STRINGDB
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
Score:  0.62
Data Source:  STRINGDB
NUDT8
Tdark
Novelty:  0.76306116
Score:  0.619
Data Source:  STRINGDB
NAXE
Tbio
Family:  Enzyme
Novelty:  0.05096435
Score:  0.601
Data Source:  STRINGDB
NUDT15
Tbio
Family:  Enzyme
Novelty:  0.008497
Score:  0.601
Data Source:  STRINGDB
TEX22
Tdark
Novelty:  3.4924613
Score:  0.589
Data Source:  STRINGDB
COMMD4
Tbio
Novelty:  0.20453574
Score:  0.578
Data Source:  STRINGDB
ZNF330
Tdark
Novelty:  0.32566699
Score:  0.564
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of dolichyl-phosphate-glucose
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of dolichyl-phosphate-glucose
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
3
3
85.6
reticulocyte count
2
2
2
82.8
neutrophil count
2
2
2
71.1
mean corpuscular hemoglobin concentration
1
1
1
64.9
platelet count
2
2
2
57.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
85.6
reticulocyte count
2
82.8
neutrophil count
2
71.1
mean corpuscular hemoglobin concentration
1
64.9
platelet count
2
57.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 14
VGNC:3342
737747
Mouse
MGI:1913424
66174
Rat
RGD:1310583
299346
Dog
nudix hydrolase 14
VGNC:49752
612707
Horse
nudix hydrolase 14 [Source:HGNC Symbol;Acc:HGNC:20141]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 14
Mouse
Rat
Dog
nudix hydrolase 14
Horse
nudix hydrolase 14 [Source:HGNC Symbol;Acc:HGNC:20141]
Publication Statistics
PubMed Score 8.51
PubMed score by year
PubTator Score 3.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title