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Tchem
NUDT1
7,8-dihydro-8-oxoguanine triphosphatase

Protein Summary
Description
Antimutagenic (PubMed:8226881, PubMed:7713500, PubMed:10608900). Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:28679043). Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress (PubMed:12857738, PubMed:24695224, PubMed:24695225). Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004). Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP (PubMed:10373420, PubMed:11139615). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). Misincorporation of oxidized nucleoside triphosphates ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339737
  • ENSP00000343439
  • ENSG00000106268
  • ENST00000343985
  • ENSP00000339503
  • ENST00000356714
  • ENSP00000349148
  • ENST00000397046
  • ENSP00000380239
  • ENST00000397048
  • ENSP00000380241
  • ENST00000397049
  • ENSP00000380242

Symbol
  • MTH1
  • MTH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
co-expressed gene
0.85
histone modification site profile
0.82
molecular function
0.81
transcription factor binding site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.89   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.89   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 104
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1