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Tbio
NUDCD3
NudC domain-containing protein 3

Protein Summary
Description
The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355451
  • ENSP00000347626
  • ENSG00000015676

Symbol
  • KIAA1068
  • NudCL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
kinase perturbation
0.91
disease perturbation
0.87
tissue sample
0.78
transcription factor
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.08   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.08   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
KLHL28
Tdark
Novelty:  1.1777024
p_int:  0.999981665
p_ni:  0.000018335
Score:  0.552
Data Source:  BioPlex,STRINGDB
KLHL26
Tdark
Novelty:  1.53240393
p_int:  0.99994138
p_ni:  0.00005862
Data Source:  BioPlex
ENC1
Tbio
Novelty:  0.01942998
p_int:  0.999898149
p_ni:  0.000101851
Score:  0.694
Data Source:  BioPlex,STRINGDB
KLHL9
Tdark
Novelty:  0.22434722
p_int:  0.999667429
p_ni:  0.000332571
Data Source:  BioPlex
KLHL6
Tbio
Novelty:  0.1573847
p_int:  0.998818951
p_ni:  0.001181049
Score:  0.193
Data Source:  BioPlex,STRINGDB
KLHL18
Tdark
Novelty:  0.52915213
p_int:  0.996259191
p_ni:  0.003740809
Score:  0.364
Data Source:  BioPlex,STRINGDB
KLHDC2
Tbio
Novelty:  0.01485159
p_int:  0.995344935
p_ni:  0.004655065
Data Source:  BioPlex
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.994599778
p_ni:  0.005400222
Score:  0.206
Data Source:  BioPlex,STRINGDB
TECPR2
Tbio
Novelty:  0.11606334
p_int:  0.993916869
p_ni:  0.006083131
Score:  0.189
Data Source:  BioPlex,STRINGDB
GAN
Tbio
Novelty:  0.01069743
p_int:  0.980008864
p_ni:  0.019991136
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
10
20
99.2
total cholesterol measurement
6
6
8
89.8
hip bone size
1
1
1
54.4
HbA1c measurement
1
1
1
49.5
apolipoprotein B measurement
1
1
1
41.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
20
99.2
total cholesterol measurement
8
89.8
hip bone size
1
54.4
HbA1c measurement
1
49.5
apolipoprotein B measurement
1
41.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NudC domain containing 3
VGNC:8706
738223
Macaque
NudC domain containing 3
699353
Mouse
MGI:2144158
209586
Horse
NudC domain containing 3
VGNC:20939
100065072
Cow
NudC domain containing 3
VGNC:32324
533678
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NudC domain containing 3
Macaque
NudC domain containing 3
Mouse
Horse
NudC domain containing 3
Cow
NudC domain containing 3
Publication Statistics
PubMed Score 3.08
PubMed score by year
PubTator Score 2.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title