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Tbio
NUDC
Nuclear migration protein nudC

Protein Summary
Description
Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation. This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321265
  • ENSP00000319664
  • ENSG00000090273

Symbol
  • HNUDC
  • MNUDC
  • NPD011
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.97
co-expressed gene
0.94
protein complex
0.94
histone modification site profile
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.64   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 356   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.64   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (258)
RRP9
Tbio
Novelty:  0.07232317
p_int:  0.997992571
p_ni:  0.002007429
Score:  0.226
Data Source:  BioPlex,STRINGDB
POC1B
Tbio
Novelty:  0.09023863
p_int:  0.991649207
p_ni:  0.008350793
Score:  0.201
Data Source:  BioPlex,STRINGDB
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.990688593
p_ni:  0.009311407
Score:  0.524
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.987155771
p_ni:  0.012844229
Score:  0.54
Data Source:  BioPlex,STRINGDB
PAFAH1B1
Tbio
Family:  Enzyme
Novelty:  0.00256206
Score:  0.995
Data Source:  STRINGDB
DYNC1H1
Tbio
Novelty:  0.0098543
Score:  0.986
Data Source:  STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
Score:  0.985
Data Source:  Reactome,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.981
Data Source:  STRINGDB
NDE1
Tbio
Novelty:  0.00567438
Score:  0.972
Data Source:  STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
Score:  0.972
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
3
8
87.9
heel bone mineral density
2
3
3
85.1
C-reactive protein measurement
2
1
3
83.1
urate measurement
2
2
2
81
monocyte percentage of leukocytes
1
1
1
80.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
8
87.9
heel bone mineral density
3
85.1
C-reactive protein measurement
3
83.1
urate measurement
2
81
monocyte percentage of leukocytes
1
80.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear distribution C, dynein complex regulator
VGNC:1420
737457
Macaque
nuclear distribution C, dynein complex regulator [Source:HGNC Symbol;Acc:HGNC:8045]
Mouse
MGI:106014
18221
Rat
RGD:3215
29648
Dog
nuclear distribution C, dynein complex regulator
VGNC:44021
487349
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear distribution C, dynein complex regulator
Macaque
nuclear distribution C, dynein complex regulator [Source:HGNC Symbol;Acc:HGNC:8045]
Mouse
Rat
Dog
nuclear distribution C, dynein complex regulator
Publication Statistics
PubMed Score 61.64
PubMed score by year
PubTator Score 36.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title