Protein Summary
Calcium-binding protein. May have a role in calcium homeostasis. Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance (By similarity). This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]
- ENST00000323688
- ENSP00000320168
- ENSG00000070081
- ENST00000529010
- ENSP00000436455
- ENST00000622082
- ENSP00000481959
- NEFA
- NEFA
- HEL-S-109
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.96 | ||
histone modification site profile | 0.88 | ||
gene perturbation | 0.72 | ||
biological term | 0.69 | ||
disease perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 146.39 (req: < 5)
Gene RIFs: 98 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 146.39 (req: >= 5)
Gene RIFs: 98 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (44)
TNNI2
Novelty: 0.02772952
p_int: 0.999999991
p_ni: 9e-9
Score: 0.391
Data Source: BioPlex,STRINGDB
PLA2G2D
Family: Enzyme
Novelty: 0.01212618
p_int: 0.992960043
p_ni: 0.007039957
Data Source: BioPlex
ZNF280A
Novelty: 0.20436014
p_int: 0.990893988
p_ni: 0.009106012
Score: 0.313
Data Source: BioPlex,STRINGDB
COLEC10
Novelty: 0.02593638
p_int: 0.946306527
p_ni: 0.053693473
Score: 0.237
Data Source: BioPlex,STRINGDB
JUNB
Family: TF
Novelty: 0.00841656
p_int: 0.939211139
p_ni: 0.060788861
Score: 0.167
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (8)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
10 | 6 | 2 | 1.1 | 97.8 | |||||
myeloperoxidase measurement | 1 | 1 | 1 | 78.6 | |||||
mean platelet volume | 2 | 2 | 2 | 70.4 | |||||
ganglion cell inner plexiform layer thickness measurement | 1 | 1 | 1 | 59.8 | |||||
platelet count | 1 | 1 | 1 | 59 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
2 | 1.1 | 97.8 | |||||
myeloperoxidase measurement | 1 | 78.6 | |||||
mean platelet volume | 2 | 70.4 | |||||
ganglion cell inner plexiform layer thickness measurement | 1 | 59.8 | |||||
platelet count | 1 | 59 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | nucleobindin 2 | VGNC:3085 | 748720 | |||||
Macaque | nucleobindin 2 | 697084 | ||||||
Mouse | MGI:1858179 | 53322 | ||||||
Rat | RGD:620888 | 59295 | ||||||
Dog | nucleobindin 2 | VGNC:44020 | 476876 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | nucleobindin 2 | |||||
Macaque | nucleobindin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nucleobindin 2 | |||||
Publication Statistics
PubMed Score 146.39
PubMed score by year
PubTator Score 190.71
PubTator score by year
Related Publications
Text Mined References (113)
GeneRif Annotations (98)
Items per page:
0 of 0
PMID | Year | Title |
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