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Tbio
NUCB2
Nucleobindin-2

Protein Summary
Description
Calcium-binding protein. May have a role in calcium homeostasis. Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance (By similarity). This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323688
  • ENSP00000320168
  • ENSG00000070081
  • ENST00000529010
  • ENSP00000436455
  • ENST00000622082
  • ENSP00000481959

Symbol
  • NEFA
  • NEFA
  • HEL-S-109
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
histone modification site profile
0.88
gene perturbation
0.72
biological term
0.69
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.39   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.39   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
TNNI2
Tbio
Novelty:  0.02772952
p_int:  0.999999991
p_ni:  9e-9
Score:  0.391
Data Source:  BioPlex,STRINGDB
CEBPG
Tbio
Family:  TF
Novelty:  0.07956633
p_int:  0.999996006
p_ni:  0.000003994
Data Source:  BioPlex
NUCB1
Tchem
Novelty:  0.0040312
p_int:  0.999893244
p_ni:  0.000106756
Data Source:  BioPlex
TREM2
Tbio
Novelty:  0.00228007
p_int:  0.994823935
p_ni:  0.005176065
Data Source:  BioPlex
PLA2G2D
Tchem
Family:  Enzyme
Novelty:  0.01212618
p_int:  0.992960043
p_ni:  0.007039957
Data Source:  BioPlex
ZNF280A
Tdark
Novelty:  0.20436014
p_int:  0.990893988
p_ni:  0.009106012
Score:  0.313
Data Source:  BioPlex,STRINGDB
COLEC10
Tbio
Novelty:  0.02593638
p_int:  0.946306527
p_ni:  0.053693473
Score:  0.237
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.946061679
p_ni:  0.053938321
Data Source:  BioPlex
JUNB
Tbio
Family:  TF
Novelty:  0.00841656
p_int:  0.939211139
p_ni:  0.060788861
Score:  0.167
Data Source:  BioPlex,STRINGDB
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.913584499
p_ni:  0.086415501
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
10
6
2
1.1
97.8
myeloperoxidase measurement
1
1
1
78.6
mean platelet volume
2
2
2
70.4
ganglion cell inner plexiform layer thickness measurement
1
1
1
59.8
platelet count
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
97.8
myeloperoxidase measurement
1
78.6
mean platelet volume
2
70.4
ganglion cell inner plexiform layer thickness measurement
1
59.8
platelet count
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleobindin 2
VGNC:3085
748720
Macaque
nucleobindin 2
697084
Mouse
MGI:1858179
53322
Rat
RGD:620888
59295
Dog
nucleobindin 2
VGNC:44020
476876
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleobindin 2
Macaque
nucleobindin 2
Mouse
Rat
Dog
nucleobindin 2
Publication Statistics
PubMed Score 146.39
PubMed score by year
PubTator Score 190.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title