You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

Protein Summary
Description
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure. This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262302
  • ENSP00000262302
  • ENSG00000095906

Symbol
  • CFD1
  • CIAO6
  • NBP 2
  • NUBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
histone modification site profile
0.76
protein domain
0.73
kinase perturbation
0.71
transcription factor binding site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.97   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.97   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
QPCT
Tchem
Family:  Enzyme
Novelty:  0.01687113
p_int:  0.759777052
p_ni:  0.240222948
Score:  0.685
Data Source:  BioPlex,STRINGDB
CIAO3
Tbio
Novelty:  0.00627147
Score:  0.988
Data Source:  STRINGDB
CIAO1
Tbio
Novelty:  0.03999673
Score:  0.983
Data Source:  STRINGDB
CIAPIN1
Tbio
Novelty:  0.01359005
Score:  0.983
Data Source:  STRINGDB
NDOR1
Tbio
Family:  Enzyme
Novelty:  0.07400532
Score:  0.98
Data Source:  STRINGDB
MMS19
Tbio
Novelty:  0.01978769
Score:  0.973
Data Source:  STRINGDB
NUBP1
Tbio
Novelty:  0.03429412
Score:  0.97
Data Source:  Reactome,STRINGDB
CIAO2B
Tbio
Novelty:  0.09725962
Score:  0.967
Data Source:  STRINGDB
ABCB7
Tbio
Family:  Transporter
Novelty:  0.00985796
Score:  0.965
Data Source:  STRINGDB
RTEL1
Tbio
Family:  Enzyme
Novelty:  0.00761538
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Cytosolic iron-sulfur cluster assembly (R-HSA-2564830)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic iron-sulfur cluster assembly
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic iron-sulfur cluster assembly
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
7
7
91
appendicular lean mass
3
1
3
81.9
blood metabolite measurement
1
1
1
57.3
threonine measurement
1
1
0
7.9
54
sex hormone-binding globulin measurement
2
1
2
45.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
7
91
appendicular lean mass
3
81.9
blood metabolite measurement
1
57.3
threonine measurement
0
7.9
54
sex hormone-binding globulin measurement
2
45.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleotide binding protein 2
VGNC:5855
453827
Macaque
nucleotide binding protein 2
702962
Mouse
MGI:1347072
26426
Rat
RGD:1305113
287125
Dog
nucleotide binding protein 2
VGNC:44018
609980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleotide binding protein 2
Macaque
nucleotide binding protein 2
Mouse
Rat
Dog
nucleotide binding protein 2
Publication Statistics
PubMed Score 80.97
PubMed score by year
PubTator Score 7.88
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title