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Tclin
NTRK2
BDNF/NT-3 growth factors receptor

Protein Summary
Description
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through P ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277120
  • ENSP00000277120
  • ENSG00000148053
  • ENST00000304053
  • ENSP00000306167
  • ENST00000323115
  • ENSP00000314586
  • ENST00000359847
  • ENSP00000352906
  • ENST00000376208
  • ENSP00000365381
  • ENST00000376213
  • ENSP00000365386
  • ENST00000376214
  • ENSP00000365387
  • ENST00000395882
  • ENSP00000379221

Symbol
  • TRKB
  • OBHD
  • TRKB
  • trk-B
  • EIEE58
  • GP145-TrkB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
biological term
0.97
PubMedID
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1649.3   (req: < 5)
Gene RIFs: 233   (req: <= 3)
Antibodies: 1219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1649.3   (req: >= 5)
Gene RIFs: 233   (req: > 3)
Antibodies: 1219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 133
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (357)
NTF4
Tbio
Novelty:  0.00192875
Score:  0.999
Data Source:  Reactome,STRINGDB
BDNF
Tchem
Novelty:  0.00006891
Score:  0.998
Data Source:  Reactome,STRINGDB
FRS2
Tbio
Novelty:  0.00654052
Score:  0.998
Data Source:  Reactome,STRINGDB
NTF3
Tbio
Novelty:  0.00089023
Score:  0.997
Data Source:  Reactome,STRINGDB
NGF
Tchem
Novelty:  0.00008139
Score:  0.992
Data Source:  STRINGDB
NGFR
Tclin
Novelty:  0.00072052
Score:  0.992
Data Source:  STRINGDB
SHC1
Tchem
Novelty:  0.00083615
Score:  0.989
Data Source:  Reactome,STRINGDB
SHC2
Tbio
Novelty:  0.00219395
Score:  0.988
Data Source:  STRINGDB
SHC3
Tbio
Novelty:  0.03638847
Score:  0.987
Data Source:  STRINGDB
GRIN2B
Tclin
Family:  IC
Novelty:  0.00035058
Score:  0.98
Data Source:  Reactome,STRINGDB
Pathways (54)
Activated NTRK2 signals through CDK5 (R-HSA-9032845)

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1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through CDK5
Reactome
Activated NTRK2 signals through FRS2 and FRS3
Reactome
Activated NTRK2 signals through FYN
Reactome
Activated NTRK2 signals through PI3K
Reactome
Activated NTRK2 signals through PLCG1
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through CDK5
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FYN
Activated NTRK2 signals through PI3K
Activated NTRK2 signals through PLCG1
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (67)
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Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
3
3
60.9
mathematical ability
3
2
3
38.7
self reported educational attainment
1
1
1
30.2
1
1
1
27.3
ankle brachial index
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
60.9
mathematical ability
3
38.7
self reported educational attainment
1
30.2
1
27.3
ankle brachial index
1
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurotrophic receptor tyrosine kinase 2
VGNC:8916
735394
Macaque
neurotrophic receptor tyrosine kinase 2
709757
Mouse
MGI:97384
18212
Rat
RGD:3213
25054
Dog
neurotrophic receptor tyrosine kinase 2
VGNC:44012
484147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurotrophic receptor tyrosine kinase 2
Macaque
neurotrophic receptor tyrosine kinase 2
Mouse
Rat
Dog
neurotrophic receptor tyrosine kinase 2
Publication Statistics
PubMed Score 1649.30
PubMed score by year
PubTator Score 680.64
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title