Protein Summary
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]
- ENST00000370065
- ENSP00000359082
- ENSG00000162631
- ENST00000370066
- ENSP00000359083
- ENST00000370067
- ENSP00000359084
- ENST00000370068
- ENSP00000359085
- ENST00000370071
- ENSP00000359088
- ENST00000370073
- ENSP00000359090
- ENST00000370074
- ENSP00000359091
- KIAA0976
- LMNT1
- Lmnt1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.75 | ||
PubMedID | 0.7 | ||
transcription factor | 0.7 | ||
disease | 0.6 | ||
kinase perturbation | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.09 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 140 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.09 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 140 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (154)
Nearest Tclin Targets
Pathways (10)
Reactome (3)
KEGG (2)
PathwayCommons (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational modification: synthesis of GPI-anchored proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational modification: synthesis of GPI-anchored proteins | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | SynGO-UCL | |||
Inferred from Genetic Interaction (IGI) | SynGO-UCL | |||
Disease Associations (null)
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 3 | 6 | 96.3 | |||||
testosterone measurement | 3 | 3 | 3 | 91.9 | |||||
body mass index | 3 | 4 | 4 | 70.5 | |||||
serum gamma-glutamyl transferase measurement | 2 | 2 | 2 | 70.5 | |||||
bilirubin measurement | 1 | 1 | 1 | 44.2 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 96.3 | |||||
testosterone measurement | 3 | 91.9 | |||||
body mass index | 4 | 70.5 | |||||
serum gamma-glutamyl transferase measurement | 2 | 70.5 | |||||
bilirubin measurement | 1 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | netrin G1 | VGNC:1421 | 457074 | |||||
Macaque | netrin G1 | 694410 | ||||||
Mouse | MGI:1934028 | 80883 | ||||||
Dog | netrin G1 [Source:HGNC Symbol;Acc:HGNC:23319] | |||||||
Horse | netrin G1 | VGNC:20925 | 100060362 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | netrin G1 | |||||
Macaque | netrin G1 | |||||
Mouse | ||||||
Dog | netrin G1 [Source:HGNC Symbol;Acc:HGNC:23319] | |||||
Horse | netrin G1 | |||||
Publication Statistics
PubMed Score 21.09
PubMed score by year
PubTator Score 23.51
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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