Protein Summary
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]
- ENST00000370065
- ENSP00000359082
- ENSG00000162631
- ENST00000370066
- ENSP00000359083
- ENST00000370067
- ENSP00000359084
- ENST00000370068
- ENSP00000359085
- ENST00000370071
- ENSP00000359088
- ENST00000370073
- ENSP00000359090
- ENST00000370074
- ENSP00000359091
- KIAA0976
- LMNT1
- Lmnt1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.75 | ||
PubMedID | 0.7 | ||
transcription factor | 0.7 | ||
disease | 0.6 | ||
kinase perturbation | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.27 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 140 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.27 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 140 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0