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Tchem
NTMT1
N-terminal Xaa-Pro-Lys N-methyltransferase 1

Protein Summary
Description
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372480
  • ENSP00000361558
  • ENSG00000148335
  • ENST00000372481
  • ENSP00000361559
  • ENST00000372483
  • ENSP00000361561
  • ENST00000372486
  • ENSP00000361564
  • ENST00000611055
  • ENSP00000483489
  • ENST00000613644
  • ENSP00000478521

Symbol
  • C9orf32
  • METTL11A
  • NRMT
  • NRMT1
  • NRMT
  • NRMT1
  • NTM1A
  • AD-003
  • HOMT1A
  • C9orf32
  • METTL11A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
tissue sample
0.69
transcription factor
0.61
transcription factor perturbation
0.54
histone modification site profile
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.11   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.11   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0