Protein Summary
Seems to promote the survival of visceral and proprioceptive sensory neurons. The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
- ENST00000331010
- ENSP00000328738
- ENSG00000185652
- ENST00000423158
- ENSP00000397297
- NT3
- HDNF
- NGF2
- NT-3
- NGF-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.99 | ||
gene perturbation | 0.97 | ||
biological term | 0.77 | ||
disease | 0.77 | ||
chemical | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1223.42 (req: < 5)
Gene RIFs: 80 (req: <= 3)
Antibodies: 578 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1223.42 (req: >= 5)
Gene RIFs: 80 (req: > 3)
Antibodies: 578 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 30
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0