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Tbio
NTAN1
Protein N-terminal asparagine amidohydrolase

Protein Summary
Description
N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn. The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287706
  • ENSP00000287706
  • ENSG00000157045
  • ENST00000620176
  • ENSP00000484380
  • ENSG00000275779

Symbol
  • PNAA
  • PNAD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
transcription factor perturbation
0.88
histone modification site profile
0.82
cell type or tissue
0.75


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.17   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.17   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
p_int:  0.999999215
p_ni:  7.85e-7
Score:  0.485
Data Source:  BioPlex,STRINGDB
CHST2
Tbio
Family:  Enzyme
Novelty:  0.04128083
Score:  0.938
Data Source:  STRINGDB
CHST4
Tbio
Family:  Enzyme
Novelty:  0.02345662
Score:  0.904
Data Source:  STRINGDB
SELL
Tchem
Novelty:  0.00030025
Score:  0.827
Data Source:  STRINGDB
MADCAM1
Tbio
Novelty:  0.00325843
Score:  0.794
Data Source:  STRINGDB
ATE1
Tbio
Family:  Enzyme
Novelty:  0.01672896
Score:  0.752
Data Source:  STRINGDB
PDXDC1
Tbio
Family:  Enzyme
Novelty:  0.16529476
Score:  0.72
Data Source:  STRINGDB
CCL21
Tbio
Novelty:  0.00130736
Score:  0.702
Data Source:  STRINGDB
EMCN
Tbio
Novelty:  0.01537879
Score:  0.696
Data Source:  STRINGDB
RRN3
Tbio
Family:  Enzyme
Novelty:  0.01643149
Score:  0.692
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
6
4
9
95.6
blood metabolite measurement
4
4
5
94.3
omega-6 polyunsaturated fatty acid measurement
2
2
3
94
sex hormone-binding globulin measurement
6
2
6
89.8
high density lipoprotein cholesterol measurement
2
2
3
88.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
95.6
blood metabolite measurement
5
94.3
omega-6 polyunsaturated fatty acid measurement
3
94
sex hormone-binding globulin measurement
6
89.8
high density lipoprotein cholesterol measurement
3
88.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-terminal asparagine amidase
VGNC:13753
107968797
Macaque
N-terminal asparagine amidase
100427569
Mouse
MGI:108471
18203
Dog
N-terminal asparagine amidase
VGNC:54051
609485
Horse
N-terminal asparagine amidase
VGNC:20918
100053937
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-terminal asparagine amidase
Macaque
N-terminal asparagine amidase
Mouse
Dog
N-terminal asparagine amidase
Horse
N-terminal asparagine amidase
Publication Statistics
PubMed Score 98.17
PubMed score by year
PubTator Score 78.01
PubTator score by year
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Related Publications
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PMID
Year
Title