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Tchem
NT5M
5'(3')-deoxyribonucleotidase, mitochondrial

Protein Summary
Description
Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389022
  • ENSP00000373674
  • ENSG00000205309

Symbol
  • DNT2
  • mdN
  • dNT2
  • dNT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
cell type or tissue
0.72
small molecule perturbation
0.66
transcription factor binding site profile
0.66
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.96   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.96   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (136)
TYMP
Tclin
Family:  Enzyme
Novelty:  0.0015906
Score:  0.969
Data Source:  STRINGDB
AK3
Tbio
Family:  Kinase
Novelty:  0.02673466
Score:  0.969
Data Source:  STRINGDB
CMPK2
Tbio
Family:  Kinase
Novelty:  0.01285082
Score:  0.951
Data Source:  STRINGDB
DTYMK
Tbio
Family:  Kinase
Novelty:  0.00746576
Score:  0.947
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.938
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.938
Data Source:  STRINGDB
NT5C1A
Tbio
Family:  Enzyme
Novelty:  0.00634411
Score:  0.933
Data Source:  STRINGDB
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
Score:  0.931
Data Source:  STRINGDB
NT5C1B
Tbio
Family:  Enzyme
Novelty:  0.09140009
Score:  0.928
Data Source:  STRINGDB
NT5C2
Tbio
Family:  Enzyme
Novelty:  0.00758288
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets (32)
Explore Nearest Tclin Targets
1 – 5 of 26
TYMS
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE6A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE6H
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE10A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (15)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Pyrimidine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Pyrimidine catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
83.9
heel bone mineral density
2
2
2
74
neutrophil percentage of leukocytes
1
1
1
31.4
mean corpuscular volume
1
1
1
24.4
serum alanine aminotransferase measurement
1
1
0
5.7
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
83.9
heel bone mineral density
2
74
neutrophil percentage of leukocytes
1
31.4
mean corpuscular volume
1
24.4
serum alanine aminotransferase measurement
0
5.7
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5',3'-nucleotidase, mitochondrial
VGNC:9486
454474
Chicken
5',3'-nucleotidase, mitochondrial
CGNC:3594
416505
Anole lizard
5',3'-nucleotidase, mitochondrial
100568141
Xenopus
5',3'-nucleotidase, mitochondrial [Source:Xenbase;Acc:XB-GENE-5879843]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5',3'-nucleotidase, mitochondrial
Chicken
5',3'-nucleotidase, mitochondrial
Anole lizard
5',3'-nucleotidase, mitochondrial
Xenopus
5',3'-nucleotidase, mitochondrial [Source:Xenbase;Acc:XB-GENE-5879843]
Publication Statistics
PubMed Score 25.96
PubMed score by year
PubTator Score 14.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title