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Tdark
NT5DC1
5'-nucleotidase domain-containing protein 1

Protein Summary
Description
While the exact function of the protein encoded by this gene is not known, it belongs to the 5'(3')-deoxyribonucleotidase family. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319550
  • ENSP00000326858
  • ENSG00000178425

Symbol
  • NT5C2L1
  • LP2642
  • NT5C2L1
  • C6orf200
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
cell type or tissue
0.72
histone modification site profile
0.67
transcription factor binding site profile
0.67
trait
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.77   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.77   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
PKLR
Tbio
Family:  Kinase
Novelty:  0.00268398
p_int:  0.99957282
p_ni:  0.000347294
p_wrong:  0.000079885
Score:  0.537
Data Source:  BioPlex,STRINGDB
GFAP
Tbio
Novelty:  0.00020932
p_int:  0.996732209
p_ni:  0.003267791
Score:  0.546
Data Source:  BioPlex,STRINGDB
HSP90AA4P
Tdark
p_int:  0.964017153
p_ni:  0.035974268
p_wrong:  0.000008579
Data Source:  BioPlex
ZCCHC4
Tdark
Novelty:  0.3370692
Score:  0.678
Data Source:  STRINGDB
TSPYL4
Tdark
Novelty:  0.4538252
Score:  0.646
Data Source:  STRINGDB
OR6C65
Tdark
Family:  oGPCR
Novelty:  22.4
Score:  0.641
Data Source:  STRINGDB
SEC23IP
Tbio
Novelty:  0.0925721
Score:  0.559
Data Source:  STRINGDB
NUDT8
Tdark
Novelty:  0.76306116
Score:  0.558
Data Source:  STRINGDB
CTXN2
Tdark
Novelty:  0.37741421
Score:  0.543
Data Source:  STRINGDB
CEP85L
Tbio
Novelty:  0.23631446
Score:  0.511
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
3
3
83.1
serum alanine aminotransferase measurement
2
2
1
6.9
77.4
total cholesterol measurement
4
4
4
74.7
high density lipoprotein cholesterol measurement
1
1
1
67.8
refractive error measurement
2
2
1
6.5
64.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
83.1
serum alanine aminotransferase measurement
1
6.9
77.4
total cholesterol measurement
4
74.7
high density lipoprotein cholesterol measurement
1
67.8
refractive error measurement
1
6.5
64.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase domain containing 1
VGNC:3599
462954
Macaque
5'-nucleotidase domain containing 1
716178
Mouse
MGI:2442446
319638
Dog
5'-nucleotidase domain containing 1
VGNC:54336
475036
Horse
5'-nucleotidase domain containing 1
VGNC:20915
100072637
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase domain containing 1
Macaque
5'-nucleotidase domain containing 1
Mouse
Dog
5'-nucleotidase domain containing 1
Horse
5'-nucleotidase domain containing 1
Publication Statistics
PubMed Score 2.77
PubMed score by year
PubTator Score 1.64
PubTator score by year
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Related Publications
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PMID
Year
Title